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Branched amphiphilic polysulfides: influence of macromolecular architecture on self-assembly and oxidation responsiveness

Published online by Cambridge University Press:  28 May 2015

Richard d’Arcy  and
Nicola Tirelli
Richard d’Arcy
Affiliation:
Centre for Tissue Injury & Repair, Institute of Inflammation and Repair, University of Manchester, Oxford Road, Manchester, M13 9PT, United Kingdom
Nicola Tirelli*
Affiliation:
Centre for Tissue Injury & Repair, Institute of Inflammation and Repair, University of Manchester, Oxford Road, Manchester, M13 9PT, United Kingdom North West Centre for Advanced Drug Delivery, Manchester Pharmacy School, University of Manchester, Oxford Road, Manchester, M13 9PT, United Kingdom
*
*to whom correspondence should be addressed. [email protected]
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Abstract

2-, 4-, 6- and 8-arm star amphiphilic block copolymers were prepared with the branching point located in the hydrophobic core composed of poly(propylene sulfide) (PPS); poly(ethylene glycol) (PEG) pendant chains completed the macromolecular structure. The level of branching influenced the rigidity of the PPS core and of the overall macromolecule, with the Mark-Houwink parameter a gradually approaching the value typical of globules for 6 and 8 arms. A binary behavior (linear vs. branched) was noticed for the kinetics of oxidation by H2O2 and the stability of the colloidal aggregates formed in water: irrespective of the number of arms, all branched polymers showed a slower response (to oxidation) and a more stable hydrophobic domains (a critical micellar concentration < 0.01 mg/mL).

Keywords

polymerizationself-assemblyoxidation
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1718: Symposium B – Multifunctional Polymeric and Hybrid Materials , 2015 , pp. 55 - 63
Copyright
Copyright © Materials Research Society 2015 

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References

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