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The Application of Energetic SHS Reactions in the Synthesis of Multi-functional Bone Tissue Engineering and Drug Delivery Systems

Published online by Cambridge University Press:  26 February 2011

Reed Ayers ,
Doug Burkes ,
Guglielmo Gottoli ,
H.C. Yi ,
Jaque Guigné  and
John Moore
Reed Ayers
Affiliation:
[email protected], Colorado School Of Mines, Metallurgical and Materials Engineering, 1500 Illinois St., Golden, CO, 80401, United States, 303-384-2337, 303384-2327
Doug Burkes
Affiliation:
[email protected], Colorado School Of Mines, Metallurgical and Materials Engineering, United States
Guglielmo Gottoli
Affiliation:
[email protected], Colorado School Of Mines, Metallurgical and Materials Engineering
H.C. Yi
Affiliation:
[email protected], Guigne Space Systems, United States
Jaque Guigné
Affiliation:
[email protected], Guigne Space Systems, United States
John Moore
Affiliation:
[email protected], Colorado School Of Mines, Metallurgical and Materials Engineering
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Abstract

The term combustion synthesis, or self-propagating high temperature synthesis (SHS), refers to an exothermic chemical reaction process that utilizes the heat generated by the exothermic reaction to ignite and sustain a propagating combustion wave through the reactants to produce the desired product(s). The products of combustion synthesis normally are extremely porous: typically 50 percent of theoretical density

Advantages of combustion synthesis over traditional processing routes, e.g., sintering, in the production of advanced materials such as ceramics, intermetallic compounds and composites include process economics, simplicity of operation, and low energy requirements. However, the high exothermicity and rapid combustion propagation rates necessitate a high degree of control of these reactions.

One research area being conducted in the Institute for Space Resources (ISR) at the Colorado School of Mines (CSM) is the application of combustion synthesis (SHS) to synthesize advanced, engineered porous multiphase/heterogeneous calcium phosphate (HCaP), NiTi, NiTi-TiC, TiB-Ti, TiC-Ti for bone tissue engineering and drug delivery systems. Such material systems require a complex combination of properties that can be truly classified as multi-functional materials. The range of properties includes: an overall porosity of 40-60% with a pore size of 200-500 μm; mechanical properties (compression strength and Young’s modulus) that match those of natural bone to avoid ‘stress shielding’; and a surface chemistry that is capable of facilitating bone growth and mineralization.

The paper will discuss the synthesis of porous multiphase/heterogeneous calcium phosphate (HCaP), NiTi, NiTi-TiC, TiB-Ti, TiC-Ti for bone tissue engineering and drug delivery systems.

Keywords

combustion synthesisboneceramic
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 896: Symposium H – Multifunctional Energetic Materials , 2005 , 0896-H01-07
Copyright
Copyright © Materials Research Society 2006

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References

1) Greene, D, Pruitt, L, Maas, C S, Laryngoscope. 107, 957–962 (1997).Google Scholar
2) Klawitter, J J, Hulbert, S F, J Biomed Mater Res Symp. 2, 161–229 (1971).Google Scholar
3) Hulbert, S F, Young, F A, Mathews, R S, Klawitter, J J, Talbert, C D Stelling, F H, J Biomed Mater Res. 4, 433–456 (1970).Google Scholar
4) Ripamonti, U, Petit, J C, Moehl, T, van den, Heever B, van, Wyk J, J Cranio Maxillo Fac Surg. 21, 302–308 (1993).Google Scholar
5) Kent, J N, Zide, F, Otolarynogol Clin North Am. 17, 273–319 (1984)Google Scholar
6) Wolford, L M, Wardrop, R W, Hartog, J M, J Oral Maxillofac Surg. 45, 1034–1042 (1987).Google Scholar
7) Eppley, B L, Sadove, A M, J Craniofac Surg. 1, 191–195 (1990).Google Scholar
8) Bragdon, C R, Burke, D, Lowenstein, J D, O'Connor, D O, Ramamurti, B, Jasty, M, Harris, W H, J Arthroplasty. 11, 945–951 (1996).Google Scholar
9) Ramaurti, B S, Orr, T E, Bragdon, C R, Lowenstein, J D, Jasty, M, Harris, W H, J Biomed Mater Res. 36, 274–280 (1997).Google Scholar
10) Phillips, J H, Forrest, C R, Gruss, J S, Clin Plast Surg. 19, 41–58 (1992).Google Scholar
11) Szachowicz, E H, Otolaryngol Clin North Am. 28, 865–880 (1995).Google Scholar
12) Desilets, C P, Marden, L J, Patterson, A L, Hollinger, J O, J Craniofac Surg. 1, 150–153 (1992).Google Scholar
13) Motoki, D S, Mulliken, J B, Clin Plast Surg. 17, 527–544 (1990).Google Scholar
14) Eggli, P S, Müller, W, Schenk, R K, Clin Orthop. 232, 127–138 (1988).Google Scholar
15) Light, M, Kanat, I O, J Foot Surg. 30, 472–476 (1991).Google Scholar
16) Holmes, R E, Wardrop, R W, Wolford, L M, J Oral Maxillofac Surg. 46, 661–671 (1988).Google Scholar
17) Ayers, R A, Wolford, L M, Bateman, T A, Ferguson, V L, Simske, S J,. J Biomed Mater Res. 47, 54–59 (1999).Google Scholar
18) Nunes, C R, Simske, S J, Sachdeva, R, Wolford, L M, J Biomed Mater Res. 36, 560–563 (1997).Google Scholar
19) Jahn, A F, Laryngoscope. 102, 289–299 (1992).Google Scholar
20) Engh, C A, Bugbee, W D, “Extensively porous-coated femoral stems,”in Hip surgery: Materials and developments. Sedel, L, Cabanela, M E (eds.), (Mosby, St. Louis, 1998) pp. 243–252.Google Scholar
21) Ducheyne, P,”Bioactive cement phosphate ceramics and glasses,” Hip surgery: Materials and developments Sedel, L, Cabanela, M E (eds.), (Mosby, St. Louis, 1998) pp. 75–82.Google Scholar
22) Ayers, R A, Neilsen-Priess, S, Ferguson, V, Gotolli, G, Moore, J J, Kleebe, H J,. Mat Sci and Eng C. In Press, (2005).Google Scholar
23) Gottoli, G, Ayers, R, Schowengerdt, F, Moore, J, Trans Soc for Biomat, 29, 239 (2003).Google Scholar
24) lickorish, D, Ramshaw, J A M, Werkmeister, J A, Glattauer, V, Howlett, C R,. J Biomed Mater Res. 68A, 19–27 (2004).Google Scholar
25) El-Ghannam, A, Ducheyne, P, Shapiro, I M, J Biomed Mater Res, 36, 167–180 (1997).Google Scholar
26) Simske, S J, Sachdeva, R, J Biomed Mater Res. 29, 527–533 (1995).Google Scholar
27) Ayers, R A, Simske, S J, Bateman, T A, Petkus, A, Sachdeva, R L C, Gyunter, V E, J Biomed Mater Res. 45, 42–47 (1999).Google Scholar
28) Shabalovskaya, S A, Biomed Mater Eng. 6, 267–289 (1996).Google Scholar
29). Dai, K, Biomed Mater Eng. 6, 233–240 (1996).Google Scholar
30) Airoldi, G, Riva, G, Biomed Mater Eng. 6, 299–305 (1996).Google Scholar
31) Itin, V I, Gyunter, V E, Shabalovskaya, S A, Sachdeva, R L C, Materials Characterization. 32, 179–187(1994).Google Scholar
32) Yi, H C, Moore, J J J Minerals Metals Mater Soc. 42, 31–35(1990).Google Scholar
33) Gottoli, Guglielmo. The evaluation of the biological potential of porous and dense nickel-titanium titanium-carbide composites produced by combustion synthesis (SHS) reactions via the interactions of simulated body fluids (SBF), Ph.D. Dissertation, 2005 Google Scholar
34) Belk, Denise L. Characterization of porous nickel titanium produced by self-propagating high temperature synthesis for use in biomedical applications Ph.D. Dissertation, 2005.Google Scholar
35) Lakes, R, “Composite Biomaterials,” The biomedical engineering handbook: Bronzino, J D (ed), (CRC Press, Boca Raton, 1995) pp. 598–610 Google Scholar
36) Burkes, D E, Gottoli, G, Moore, J J, Yi, H C, Ayers, R A. Mat Res Soc Symp Proc. 800, (2004).Google Scholar
37) Burkes, D E, Gottoli, G, Moore, J J and Ayers, R A. Mater. Res. Soc. Symp. Proc. 844 299–304 (2005).Google Scholar
38) Burkes, D E, Gottoli, G and Moore, J J. Submitted, Mat. Sci. Eng., (August 2005).Google Scholar
39) Cui, Y, Winton, M I, Zhang, Z F, Rainey, C, Marshall, J, De, Kernion J B, Eckhert, C D. Oncol Rep. 11, 887–92 (2004).Google Scholar
40) Dourson, M, Maier, A, Meek, B, Renwick, A, Ohanian, E, Poirier, K. Biol Trace Elem Res. 66, 453–63 (1998).Google Scholar