The use of MRI technology for studying the adhesion of microparticles

Abstract

The very synthesis of functional microparticles is generally deemed the most necessary, but obviously not the only step in successful product development. The behavior of obtained microparticles has to be tested in environments resembling the end use conditions to ensure the desired functionality. During the testing, various problems concerning particles behavior can arise, e.g. unwanted adhesion (before the successful delivering of particles to the region of interest, they will adhere somewhere else, thus hindering the delivery of transported substance), insufficient adhesion (in cases, when the particle adhesion is desired, e.g. specific adhesion for targeted delivery, the end amount of adhered particles might not be sufficient for reaching the expected concentration of released substance, meaning adhesion is not strong enough under given conditions) or particle breakage (some particles are of more fragile structure, which can result in condition limitations, in which they can exist without damage). Furthermore, regarding specific adhesion, the demonstration of such particle functionality should also be performed before testing on living organisms, preferably in conditions resembling the end use.