Hostname: page-component-586b7cd67f-rcrh6 Total loading time: 0 Render date: 2024-12-01T01:11:32.778Z Has data issue: false hasContentIssue false
  • English
  • Français

Tailoring of Mechanical Properties of Diisocyanate Crosslinked Gelatin-Based Hydrogels

Published online by Cambridge University Press:  28 June 2013

Axel T. Neffe ,
Tim Gebauer  and
Andreas Lendlein
Axel T. Neffe
Affiliation:
Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Kantstrasse 55, 14513Teltow, Germany. Department of Chemistry, University of Potsdam, Potsdam, Germany Helmholtz Virtual Institute “Multifunctional Biomaterials for Medicine”, Teltow and Berlin, Germany
Tim Gebauer
Affiliation:
Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Kantstrasse 55, 14513Teltow, Germany. Department of Chemistry, University of Potsdam, Potsdam, Germany Helmholtz Virtual Institute “Multifunctional Biomaterials for Medicine”, Teltow and Berlin, Germany
Andreas Lendlein
Affiliation:
Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Kantstrasse 55, 14513Teltow, Germany. Department of Chemistry, University of Potsdam, Potsdam, Germany Helmholtz Virtual Institute “Multifunctional Biomaterials for Medicine”, Teltow and Berlin, Germany
Get access

Abstract

Polymer network formation is an important tool for tailoring mechanical properties of polymeric materials. One option to synthesize a network is the addition of bivalent crosslinkers reacting with functional groups present in a polymer. In case of polymer network syntheses based on biopolymers, performing such a crosslinking reaction in water is sometimes necessary in view of the solubility of the biopolymer, such as gelatin, and can be beneficial to avoid potential contamination of the formed material with organic solvents in view of applications in biomedicine. In the case of applying diisocyanates for the crosslinking in water, it is necessary to show that the low molecular weight bifunctional crosslinker has fully reacted, while tailoring of the mechanical properties of the resulting hydrogels is possible despite the complex reaction mechanism. Here, the formation of gelatin-based hydrogel networks with the diisocyanates 2,4-toluene diisocyanate, 1,4-butane diisocyanate, and isophorone diisocyanate is presented. It is shown that extensive washing of materials is required to ensure full conversion of the diisocyanates. The use of different diisocyanates gives hydrogels covering a large range of Young’s moduli (12-450 kPa). The elongations at break (up to 83%) as well as the maximum tensile strengths (up to 410 kPa) of the hydrogels described here are much higher than for lysine diisocyanate ethyl ester crosslinked gelatin reported before. Rheological investigations suggest that the network formation in some cases is due to physical interactions and entanglements rather than covalent crosslink formation.

Keywords

biomaterialpolymermacromolecular structure
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1569: Symposium NN – Advanced Materials for Biological and Biomedical Applications , 2013 , pp. 3 - 8
Copyright
Copyright © Materials Research Society 2013 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Lendlein, A.; Zotzmann, J.; Feng, Y.; Alteheld, A.; Kelch, S., Biomacromolecules 2009, 10(4), 975–982.CrossRefGoogle Scholar
Neffe, A. T.; Tronci, G.; Alteheld, A.; Lendlein, A., Macromol. Chem. Phys. 2010, 211(2), 182–194.CrossRefGoogle Scholar
Hennessy, K. M.; Pollot, B. E.; Clem, W. C.; Phipps, M. C.; Sawyer, A. A.; Culpepper, B. K.; Bellis, S. L., Biomaterials 2009, 30(10), 1898–1909.CrossRefGoogle Scholar
Gornall, J. L.; Terentjev, E. M., Soft Matter 2008, 4(3), 544–549.CrossRefGoogle Scholar
Bigi, A.; Panzavolta, S.; Rubini, K., Biomaterials 2004, 25(25), 5675–5680.CrossRefGoogle Scholar
Tronci, G.; Neffe, A. T.; Pierce, B. F.; Lendlein, A., J. Mater. Chem. 2010, 20, 8875.CrossRefGoogle Scholar
Zaupa, A.; Neffe, A. T.; Pierce, B. F.; Nochel, U.; Lendlein, A., Biomacromolecules 2011, 12(1), 75–81.CrossRefGoogle Scholar
Levental, I.; Georges, P. C.; Janmey, P. A., Soft Matter, 2007, 3, 299–306.CrossRefGoogle Scholar
Jen, A.C.; Wake, M.C.; Mikos, A.G., Biotech. Bioeng. 1996, 50, 357–364.3.0.CO;2-K>CrossRefGoogle Scholar
Meissner, B., Polymer 2000, 41(21), 7827–7841.CrossRefGoogle Scholar