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Synthesis of Core-Shell Biopolymer Particles Using Coaxial Electrospray

Published online by Cambridge University Press:  10 May 2012

Cho Hui Lim  and
Michael E. Mullins
Cho Hui Lim
Affiliation:
Department of Chemical Engineering, Michigan Technological University, Houghton, MI 49931
Michael E. Mullins
Affiliation:
Department of Chemical Engineering, Michigan Technological University, Houghton, MI 49931
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Abstract

Core-shell PLLA microparticles were successfully fabricated using a novel coaxial nozzle design. These particles were synthesized with different components in the core/shell layers representing three classes of systems of interest for drug delivery applications: PVA/PLLA, PLLA/PEG, and oleic acid/PLLA. The components were characterized for their physical properties and interfacial energies, and optimal conditions for the operation were determined. To facilitate the particle characterization, each phase was doped with a different fluorescent dye to aid in the confirmation of a core/shell structure via fluorescence microscopy.

Keywords

core/shellspray depositionbiomedical
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1418: Symposium LL/MM – Gels and Biomedical Materials , 2012 , mrsf11-1418-mm10-19
Copyright
Copyright © Materials Research Society 2012

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References

REFERENCES

1. Pui, D.Y.H. and Chen, D., U.S. Patent No. 7 951 428 (2000).Google Scholar
2. Loscertales, I.G., Barrero, A., Guerrero, I., Cortijo, R., , M. M, Ganan-Calvo, AM., Science 295 (5560), 1695–1698 (2002).CrossRefGoogle Scholar
3. López-Herrera, J. M., Barrero, A., López, A., Loscertales, I.G. and Márquez, M., Journal of Aerosol Science 34 (5), 535–552 (2003).CrossRefGoogle Scholar
4. Chen, X., Jia, L., Yin, X., Cheng, J. and Lu, J., Physics of Fluids 17 (3), 032–101 (2005).Google Scholar
5. Mei, F. and Chen, D-R., Physics of Fluids 19 (10), 103–303 (2007).CrossRefGoogle Scholar
6. Xie, J., Ng, W. J., Lee, L.Y. and Wang, C-H., Journal of Colloid and Interface Science 317 (2), 469–476 (2008).CrossRefGoogle Scholar
7. Rhodamine, B <http://dbc.bio.uci.edu/OBCresources/fluorophores.pdf>..>Google Scholar
8. Fluorescein. <http://dbc.bio.uci.edu/OBCresources/fluorophores.pdf>..>Google Scholar
9. Coumarin 6. <http://www.ecse.rpi.edu/~schubert/Light-Emitting-Diodes-dotorg/chap21/chap21.htm>..>Google Scholar
10. Hayati, I., Bailey, A. and Tadros, T.F.., Journal of Colloid and Interface Science 117 (1), 222 (1987).CrossRefGoogle Scholar