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Stable, Hydrophilic Nitrilotriacetic Acid-Capped Gold Monolayer Protected Clusters

Published online by Cambridge University Press:  01 February 2011

Ndabenhle M. Sosibo ,
Robert T. Tshikhudo  and
Neerish Revaprasadu
Ndabenhle M. Sosibo
Affiliation:
sosibonm@yahoo.com, University of Zululand, Department of Chemistry, Private Bag X1001, KwaDlangezwa, 3886, South Africa
Robert T. Tshikhudo
Affiliation:
robertt@mintek.co.za, Mintek, Advanced Materials Division, 200 Hans Strijdom Drive, Randburg, 2125, South Africa
Neerish Revaprasadu
Affiliation:
nrevapra@pan.uzulu.ac.za, University of Zululand, Department of Chemistry, Private Bag X1001, KwaDlangezwa, 3886, South Africa
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Abstract

A one step synthesis and functionalization of robust, hydrophilic monolayer protected clusters of gold (Au-MPCs) containing a nitrilotriacetic acid (NTA) is described. The 14 nm Au-MPCs were prepared by the attachment of two bifunctional thioalkylated-poly(ethylene glycol) ligands on the nanoparticles, one containing a nitrilotriacetic acid (NTA) terminal group, while the second hydroxyl (OH) terminated ligand was used as a co-stabilizer to promote the stability of the MPCs. The resulting PEGylated NTA functionalized Au MPCs, which are characterized by TEM, UV-vis and agarose gel electrophoresis are attractive probes for many target species e.g. hexahistidine-tagged proteins. Importantly, the NTA functionality on MPCs ligand shell can be varied.

Keywords

Aucolloidnanostructure
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1064: Symposium PP – Quantum-Dot and Nanoparticle Bioconjugates–Tools for Sensing and Biomedical Imaging , 2007 , 1064-PP03-10
Copyright
Copyright © Materials Research Society 2008

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