Hostname: page-component-586b7cd67f-r5fsc Total loading time: 0 Render date: 2024-12-01T01:32:47.129Z Has data issue: false hasContentIssue false
  • English
  • Français

A PVA-PCL Bioglass Composite with Potential Implications for Osteochondral Tissue Engineering

Published online by Cambridge University Press:  31 January 2011

Prabha D Nair ,
Lakshmi M Mukundan ,
Remya Nirmal  and
Neethu Mohan
Prabha D Nair
Affiliation:
[email protected]
Lakshmi M Mukundan
Affiliation:
[email protected], SCTIMST, DTERT, Trivandrum, India
Remya Nirmal
Affiliation:
[email protected], SCTIMST, DTERT, Trivandrum, India
Neethu Mohan
Affiliation:
[email protected], SCTIMST, DTERT, Trivandrum, India
Get access

Abstract

A bioglass of composition SiO2 (67.12 mol%), CaO (28.5 mol%), and P2O5 (4.38%) was synthesized and stabilized by a novel technique using ethanol. Bioactive glasses have a wide range of application in the field of biomaterials promoting bone bonding as well as bonding to soft tissue. Earlier our lab developed a novel PVA-PCL semi IPN porous and 3D scaffold that was found to favor chondrogenesis. In the present study, a composite of this polymer and bioglass is prepared by an emulsion freeze-drying process, as a porous 3 dimensional scaffold. The scaffolds were characterized for their physiochemical properties and ability to support cartilage tissue regeneration. The composite scaffolds were observed to be non-cytotoxic. The chondrocytes cells cultured in vitro for a month on the composite scaffolds regenerate cartilaginous tissue, secreting GAGs and collagen in amounts nearly comparable to the amounts on the control PVA-PCL scaffold. The composite scaffold is also biomimetic and bioactive and favors mineralization by forming a hydroxycarbonate apatite layer, when immersed in simulated body fluid for a 14 day period. The PVA-PCL-bioglass composite is hence expected to have potential implications as a scaffold for osteochondral tissue engineering.

Keywords

biomimetic (chemical reaction)bonetissue
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1235: Symposium RR – Engineering Biomaterials for Regenerative Medicine , 2009 , 1235-RR03-28
Copyright
Copyright © Materials Research Society 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1 LeBaron, R. G. and Athanasiou, K. A., Biomaterals 21, 2575 (2000).Google Scholar
2 Hench, L. L., Bioceramics. J. Am Ceram Soc 81, 1705 (1998).Google Scholar
3 Wilson, J. and Nolletti, D.. in Handbook on bioactive ceramics: bioactive glasses and glass ceramics edited by Yamauro, T., Hench, L. L. and Wilson, J.. (CRC publishers, 1990) p 283.Google Scholar
4 Mohan, N. and Nair, P. D.. J. Biomed. Mater. Res. 84B, 584 (2008).Google Scholar
5 Xia, W. and Chang, J.. Materials Letters 61, 3251 (2007).Google Scholar
6ISO 10993-5: 1999, Biological evaluation of medical products. Part5: Test for in vitro Cytotoxicity.Google Scholar