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Polyethylene Oxide-Polystyrene Oxide Triblock Copolymers as Biological-Responsive Nanocarriers.

Published online by Cambridge University Press:  03 September 2012

Adriana Cambón ,
Ana Rey-Rico ,
Silvia Barbosa ,
Jose Brea ,
M. I. Loza ,
Stephen G. Yeates ,
Carmen Alvarez-Lorenzo ,
Angel Concheiro ,
Pablo Taboada  and
Victor Mosquera
Adriana Cambón
Affiliation:
Grupo de Física de Coloides y Polímeros, Facultad de Física, Universidad de Santiago de Compostela, Spain.
Ana Rey-Rico
Affiliation:
Departamento de Farmacia y Tecnología Farmacéutica, Universidad de Santiago de Compostela, Spain.
Silvia Barbosa*
Affiliation:
Grupo de Física de Coloides y Polímeros, Facultad de Física, Universidad de Santiago de Compostela, Spain.
Jose Brea
Affiliation:
Departamento de Farmacología, Universidad de Santiago de Compostela, Spain.
M. I. Loza
Affiliation:
Departamento de Farmacología, Universidad de Santiago de Compostela, Spain.
Stephen G. Yeates
Affiliation:
Organic Materials Innovation Center, School of Chemistry, University of Manchester, UK.
Carmen Alvarez-Lorenzo
Affiliation:
Departamento de Farmacia y Tecnología Farmacéutica, Universidad de Santiago de Compostela, Spain.
Angel Concheiro
Affiliation:
Departamento de Farmacia y Tecnología Farmacéutica, Universidad de Santiago de Compostela, Spain.
Pablo Taboada
Affiliation:
Grupo de Física de Coloides y Polímeros, Facultad de Física, Universidad de Santiago de Compostela, Spain.
Victor Mosquera
Affiliation:
Grupo de Física de Coloides y Polímeros, Facultad de Física, Universidad de Santiago de Compostela, Spain.
*
*Email: [email protected]
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Abstract

The present work presents the synthesis, characterization and evaluation of the biocompatibility and ability to dissolve and chemically protect the anticancer drug doxorubicin (DOXO) of two polyethylene oxide-polystyrene oxide triblock copolymers, EO33SO13EO33 and EO38SO10EO38, where EO and SO denote the ethylene oxide and styrene oxide blocks, respectively. Block copolymer length and SO/EO ratio were selected with the objective of ensuring an optimal compromise between chain solubility, micelle formation ability and core size for enhanced drug solubilization. The temporal stability of the drug-loaded micelles and drug release profile were also analyzed as well as their efficacy as an antitumoral polymeric formulation in vitro by using a multidrug resistant ovarian tumor cell line (NCI-ADR-RES), with the special aim of analyzing the possible capability of both copolymers as potential P-glycoprotein efflux (P-gp) pump inhibitors to enhance DOXO accumulation in this cell line.

Keywords

biomaterialpolymerself-assembly
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1468: Symposium VV – Nanomedicine for Molecular Imaging and Therapy , 2012 , mrss12-1468-vv05-19
Copyright
Copyright © Materials Research Society 2012

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References

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