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Novel Gelation System For Fabricating 3-D Structures via Ink Jet Printing

Published online by Cambridge University Press:  31 January 2011

Rachel E. Saunders ,
Kwan P Liem ,
Robert J Mart ,
Simon J Webb  and
Brian Derby
Rachel E. Saunders
Affiliation:
[email protected]
Kwan P Liem
Affiliation:
[email protected], The University of Manchester, Manchester Interdisciplinary Biocentre and School of Chemistry, Manchester, United Kingdom
Robert J Mart
Affiliation:
[email protected], The University of Manchester, Manchester Interdisciplinary Biocentre and School of Chemistry, Manchester, United Kingdom
Simon J Webb
Affiliation:
[email protected], The University of Manchester, Manchester Interdisciplinary Biocentre and School of Chemistry, Manchester, United Kingdom
Brian Derby
Affiliation:
[email protected], University of Manchester, School of Materials, Grosvenor Street, Manchester, M1 7HS, United Kingdom
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Abstract

Drop-on-demand inkjet printing is a fabrication technique that is capable of depositing materials layer-by-layer to form complex 3-dimensional (3-D) constructs. Here we present a new single drop delivery method in which both the matrix and cross-linker are present but separated through the use of vesicle packaging. Changing the printing parameters has little effect on the integrity of the calcium(II)-loaded vesicles, with calcium(II) released selectively by warming after printing. Alginate solutions containing calcium(II)-loaded vesicles were successfully printed and the printed layers were shown to gel on demand at 37 °C. The printed alginate layers were evaluated with regards to their potential to provide 3-D structures for cell culture.

Keywords

ink-jet printingtissuepiezoelectric
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1239: Symposium VV – Micro- and Nanoscale Processing of Biomaterials , 2009 , 1239-VV06-10
Copyright
Copyright © Materials Research Society 2010

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References

1 Saunders, R.E. Gough, J.E. and Derby, B. Biomaterials. 29, 193 (2008).Google Scholar
2 Xu, T.., Gregory, C.A. Molnar, P. Cui, X. Jalota, S. Bhaduri, S.B. and Boland, T. Biomaterials, 27, 3580 (2006).Google Scholar
3 Nakamura, M., Kobayashi, A. Takagi, F. Watanabe, A. Hiruma, Y. Ohuchi, K. Iwasaki, Y. Horie, M. Morita, I. and Takatani, S. Tissue Engineering, 11, 1658 (2005).Google Scholar
4 Lee, C.S.D, Gleghorn, J.P. Choi, N.W. Cabodi, M. Stroock, A.D. and Bonassar, L.J., Biomaterials, 28, 2987 (2007)Google Scholar
5 Lenas, P. Moos, M. and Luyten, F.P. Tissue Engineering Part B-Reviews, 15, 381 (2009)Google Scholar
6MicroFab Technologies, I., MicroFab Technote 99-02 www.microfab.com. (2009).Google Scholar
7MicroFab Technologies, I., MicroFab Technote 99-03 www.microfab.com. (2009).Google Scholar
8 Messersmith, P.B. and Starke, S. Chemistry Of Materials. 10, 117 (1998).Google Scholar
9 Mart, R.J., Liem, K.P. and Webb, S.J. Chem. Commun. 17, 2287 (2009)Google Scholar
10 Deegan, R.D. Bakajin, O. Dupont, T.F. Huber, G. Nagel, S.R. and Witten, T.A. Nature. 389, 827 (1997)Google Scholar