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Nano- and Micro-Scale Adhesion in Drug-eluting Stents

Published online by Cambridge University Press:  31 January 2011

Ting Tan ,
Juan Meng ,
Nima Rahbar ,
Hannah Li ,
George Papandreou ,
Cynthia Maryanoff  and
Winston oluwole Soboyejo
Ting Tan
Affiliation:
[email protected], Princeton University, Princeton, United States
Juan Meng
Affiliation:
[email protected], Princeton University, princeton, United States
Nima Rahbar
Affiliation:
[email protected], Univ of Massachusetts Dartmouth, Boston, United States
Hannah Li
Affiliation:
[email protected], Cordis Company, Warren, United States
George Papandreou
Affiliation:
[email protected], Cordis Company, Warren, United States
Cynthia Maryanoff
Affiliation:
[email protected], Cordis Company, Spring House, United States
Winston oluwole Soboyejo
Affiliation:
[email protected]@aol.com, Princeton University, Olden Street, Princeton, New Jersey, 08544, United States
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Abstract

This paper presents a combined experimental and theoretical/computational study of adhesion and interfacial fracture between multilayers in a CYPHER® model drug eluting stents (DES). Atomic Force Microscopy (AFM) is used to obtain pull-off forces between coated AFM tips and substrates that simulate the bimaterial surfaces in the DES. Adhesion theories and fracture mechanics concepts are then applied to obtain estimates of the fracture toughness over a range of mode mixities between pure mode I and pure mode II. The trends in the estimates are shown to be in good agreement with experimental measurements of interfacial fracture toughness obtained from Brazil disk specimens over the same range of mode mixities.

Keywords

adhesionfracturebiomedical
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1239: Symposium VV – Micro- and Nanoscale Processing of Biomaterials , 2009 , 1239-VV01-07
Copyright
Copyright © Materials Research Society 2010

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