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Monolithic Liquid Chemical Sensing Systems

Published online by Cambridge University Press:  01 February 2011

Steven M. Martin
Affiliation:
University of Michigan, Ann Arbor, MI 48105, USA Sonetics Ultrasound, Ann Arbor, MI 48103, USA
Timothy D. Strong
Affiliation:
University of Michigan, Ann Arbor, MI 48105, USA Sensicore, Ann Arbor, MI 48108, USA
Richard B. Brown
Affiliation:
University of Michigan, Ann Arbor, MI 48105, USA University of Utah, Salt Lake City, UT 84112, USA
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Abstract

The miniaturization of electrochemical transducers is crucial for the development of implantable biosensors, wearable microdetectors, and remote sensing networks due to the small dimensions required in these applications. As sensors scale, the analytical response degrades and integrated instrumentation is required to maintain acceptable detection limits. This work details the development of CMOS-integrated liquid chemical sensors. The sensors were cost-effectively post-processed on top of foundry-fabricated CMOS electronics using thin-film techniques. CMOS-integrated voltammetric sensors demonstrated a 25x improvement in detection limit/electrode area versus passive sensors. CMOS-integrated, ion-selective electrodes demonstrated a 50x improvement in lifetime and a 200x improvement in response time versus passive sensors. With their improved performance, these smart sensors can be used in a wide range of applications and can additionally serve as enabling technologies for more complex, chip-scale systems.

Type
Research Article
Copyright
Copyright © Materials Research Society 2005

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References

1 Steenkiste, F. Van, Lauwers, E., Suls, J.et. al., “A Biochemical CMOS Integrated Multi-Parameter Microsensor,” Digest of Tech. Papers Transducers 1999, pp. 11881190, 1999.Google Scholar
2 Witvrouw, A., Steenkiste, F. Van, Maes, D.et. al., Microsystem Technologies, 6, 192199 (2000).Google Scholar
3 Bard, A. and Faulkner, L., Electrochemical Methods, (John Wiley & Sons, 1980).Google Scholar
4 Martin, S., Ha, J., Kim, J.W.et. al., “ISE Arrays with Improved Dynamic Response and Lifetime,” Tech. Digest of the Solid-State Sensor, Actuator, and Microsystems Workshop, pp. 396399, 2004.Google Scholar
5 Morf, W., The Principles of Ion-Selective Electrodes and of Membrane Transport, (Elsvier, 1981).Google Scholar
6 Strong, T., Cantor, H., and Brown, R., “A Microelectrode Array for Real-Time Neurochemical and Neuroelectrical Recording In-Vitro,” Tech. Digest of the Solid-State Sensor, Actuator, and Microsystems Workshop, pp. 2932, 2004.Google Scholar
7 Strong, T., PhD. Thesis, University of Michigan, 2004.Google Scholar
8 Martin, S., PhD. Thesis, University of Michigan, 2005.Google Scholar
9[Online] http://www.mosis.orgGoogle Scholar
10 Kissinger, P. and Heineman, W., Laboratory Techniques in Electroanalytical Chemistry 2nd Edition, Revised and Expanded, (Marcel Dekker, Inc., 1996).Google Scholar
11 Wang, J., Stripping Analysis Principles, Instrumentation, and Applications, (VCH Publishers, 1985).Google Scholar
12 Schmitt, G., Schultze, J.et. al, Electrochimica Acta, 44, 38653883 (2000).Google Scholar
13 Nam, H., Cha, G.S., Strong, T.et. al., Proc. of the IEEE, 91, 870880 (2003).Google Scholar
14 Hower, R. and Brown, R., U.S. Patent No. 6,764,652, (20 July 2004).Google Scholar
15 Martin, S., Strong, T., Brown, R., “Design, implementation, and verification of a CMOS-integrated chemical sensor system,” Proc. of the 2004 Intl. Conf. on MEMS, NANO and Smart Systems (ICMENS'04), pp. 336342, 2004.Google Scholar
16 Brown, R., PhD. Thesis, University of Utah, 1985.Google Scholar
17 Yoon, I., Lee, D., Nam, H.et. al., Jnl. of Electroanalytical Chemistry, 464, 135142 (1999).Google Scholar
18 Malinowska, E., Oklejas, V., Hower, R.W.et. al., Sensors and Actuators B, 33, 161167 (1996).Google Scholar