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Monitoring the size and the stability of zinc oxide quantum dots in biological media: a soft ionization mass spectrometry technique (MALDI-TOF-MS)

Published online by Cambridge University Press:  17 June 2015

Jean-Jacques Gaumet ,
Gabriel Gaiffe ,
Clément Dezanet ,
Stéphane Dalmasso ,
Pierre Magri ,
Lavinia Balan  and
Raphaël Schneider
Jean-Jacques Gaumet
Affiliation:
Université de Lorraine, LCP-A2MC, Jean Barriol Institute, 1 bd Arago, 57078 Metz Cedex 03, France.
Gabriel Gaiffe
Affiliation:
Université de Lorraine, LCP-A2MC, Jean Barriol Institute, 1 bd Arago, 57078 Metz Cedex 03, France.
Clément Dezanet
Affiliation:
Université de Lorraine, LRGP, CNRS, UMR 7274, 1 rue Grandville, 54001 Nancy, France
Stéphane Dalmasso
Affiliation:
Université de Lorraine, LCP-A2MC, Jean Barriol Institute, 1 bd Arago, 57078 Metz Cedex 03, France.
Pierre Magri
Affiliation:
Université de Lorraine, LCP-A2MC, Jean Barriol Institute, 1 bd Arago, 57078 Metz Cedex 03, France.
Lavinia Balan
Affiliation:
IS2M, UHA, 15 rue Jean Starcky, BP 2488, 68057 Mulhouse Cedex, France
Raphaël Schneider
Affiliation:
Université de Lorraine, LRGP, CNRS, UMR 7274, 1 rue Grandville, 54001 Nancy, France
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Abstract

We present herein a joint physical/physico-chemical study and, more specifically, the first application of Matrix Assisted Laser Desorption Ionization coupled with Time of Flight Mass Spectrometry (MALDI-TOF-MS) to analyze small-sized ZnO quantum dots (QDs) (2.8-3.1 nm diameter range) synthesized by sol-gel chemistry and stabilized through an aminosilane coating. A careful investigation of the stability of ZnO QDs was initiated once these dots were dispersed in different media (water, biological buffer) for a period up to 3 weeks. Positive ion mode mass spectra MALDI-TOF-MS combined with optical spectrometry was used to monitor the stability of ZnO QDs when aging. Such a unique combination of MALDI-TOF-MS and physico-chemical techniques is likely to bring new insights into the structure analysis, the stability and consequently the potential toxicity of QDs.

Keywords

core/shellII-VImass spectroscopy
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1793: Symposium GG – Foundations of Bio/Nano Interfaces―Synthesis, Modeling, Design Principles and Applications , 2015 , pp. 7 - 12
Copyright
Copyright © Materials Research Society 2015 

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References

REFERENCES

Thomas, K., Aguar, P., Kawasaki, H., Morris, J., Nakanishi, J. and Savage, N., Toxicol. Sci. 92(1), 23–32 (2006).CrossRefGoogle Scholar
Hutchinson, J.E, ACS Nano, 2(3) 395–4032 (2008).CrossRefGoogle Scholar
Kumar, A., Kumar, P., Anandan, A., Fernandes, T. F., Ayoko, G.A. and Biskos, G., J. Nanomater. 2014 Article ID 130198, 16 pp (2014).Google Scholar
Gaumet, J.J. and Strouse, G., Mater. Sci. Eng. C, 19, 299–304 (2002).CrossRefGoogle Scholar
Fregnaux, M., Dalmasso, S., Durand, P., Zhang, Y., Gaumet, J.J. and Laurenti, J.P., Mater. Chem. Phys, 142, 52–60 (2013).CrossRefGoogle Scholar
Fregnaux, M., Gaumet, J.J., Dalmasso, S., Laurenti, J.P. and Schneider, R., Microelectron. Eng. 108, 187–191(2013).CrossRefGoogle Scholar
Moussodia, R.O., Balan, L., Merlin, C., Mustin, C. and Schneider, R., J. Mater. Chem, 20, 1147–1155 (2010).CrossRefGoogle Scholar
Khitrov, G.A. and Strouse, G.F., J. Am. Chem. Soc., 125, 10465–10469 (2003).CrossRefGoogle Scholar
Inoue, H., Ichiroku, N., Torimoto, T., Sakata, T., Mori, H. and Yoneyama, H., Langmuir, 10, 4517–4522 (1994).CrossRefGoogle Scholar
Reschikov, M.A., Morkoc, H., Nemeth, B., Nause, J., Xie, J. J, Hertog, B. and Osinsky, A., Physica B, 401-402 358–361 (2007).CrossRefGoogle Scholar
Zhang, L., Yin, L., Wang, C., Iun, N., Qi, Y. and Xiang, D. D J. Phys. Chem. C, 114 9651–9658 (2010).CrossRefGoogle Scholar
Felbier, P., Yang, J., Theis, J., Liptak, R.W., Wagner, A., Lorke, A., Bacher, G., Korsthagen, U., Adv. Funct. Mater., 24 1988–1993 (2014).CrossRefGoogle Scholar