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Low-cost and Chemical Resistant Microfluidic Devices Based on Thermoplastic Elastomers for a Novel Biosensor System

Published online by Cambridge University Press:  01 February 2011

I. Stoyanov ,
M. Tewes ,
S. Glass ,
M. Koch  and
M. Löhndorf
I. Stoyanov
Affiliation:
Center of advanced european studies and research (caesar), Ludwig-Erhard-Allee 2, D-53175 Bonn, Germany
M. Tewes
Affiliation:
Center of advanced european studies and research (caesar), Ludwig-Erhard-Allee 2, D-53175 Bonn, Germany
S. Glass
Affiliation:
Center of advanced european studies and research (caesar), Ludwig-Erhard-Allee 2, D-53175 Bonn, Germany
M. Koch
Affiliation:
Center of advanced european studies and research (caesar), Ludwig-Erhard-Allee 2, D-53175 Bonn, Germany
M. Löhndorf
Affiliation:
Center of advanced european studies and research (caesar), Ludwig-Erhard-Allee 2, D-53175 Bonn, Germany
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Abstract

Low-cost and chemical resistant microfluidic devices based on thermoplastic elastomers have been fabricated by hot embossing technology. Commercial available thermoplastic elastomer foils based on polyurethane (PU) in a thickness range of 100-600 μm have been used. Prior to the fabrication of the microfluidic devices the chemical resistance of the material against a wide range of standard biological buffer solutions and solvents had been analysed. We created systems of channels, reservoirs and holes for the connections to external capillaries by double-sided hot embossing with an alignment accuracy of +/- 3 micrometer. Closed channel structures were produced by an additional chemical bonding process of the embossed devices with another thermoplastic elastomer foil. The total volume of the fluidic cell was 2 μl/sensor for the use with SAW (surface-acoustic wave) sensor chip and about 0.2 μ/sensor for the impedance sensors. A novel multi-chamber fluidic device was successfully tested for in-situ immobilization of thrombin antibodies and Bovin Serum Albumin (BSA) on different sensor elements of the same sensor chip.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 872: Symposium J – Micro- and Nanosystems—Materials and Devices , 2005 , J11.4
Copyright
Copyright © Materials Research Society 2005

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