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Implementation of BioMEMS for Determining Mechanical Properties of Biological Cells

Published online by Cambridge University Press:  12 January 2012

Svetlana Tatic-Lucic  and
Markus Gnerlich
Svetlana Tatic-Lucic
Affiliation:
ECE Department, Lehigh University, Bethlehem, PA, 18015, U.S.A.
Markus Gnerlich
Affiliation:
ECE Department, Lehigh University, Bethlehem, PA, 18015, U.S.A.
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Abstract

This paper describes the implementation of a custom-made bio-microelectromechanical system for determining mechanical properties of biological cells, which is used for the measurement of mechanical properties of fibroblasts. Our system consists of several subcomponents: (a) actuator which deforms the cell in pre-determined, step-wise fashion, (b) force sensor that measures force applied onto the cell, (c) set of dielectrophoretic (DEP) electrodes for positioning cells in the desired position, (d) temperature sensors and (e) heater. Preliminary results of the mechanical properties of NIH3T3 cells have been determined using this tool and our cell compression techniques.

Keywords

microelectro-mechanical (MEMS)biomedicalsensor
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1415: Symposium HH/II/TT – MEMS, BioMEMS and Bioelectronics–Materials and Devices , 2012 , mrsf11-1415-ii05-01
Copyright
Copyright © Materials Research Society 2012

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References

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