Hostname: page-component-586b7cd67f-2plfb Total loading time: 0 Render date: 2024-11-28T10:37:09.369Z Has data issue: false hasContentIssue false
  • English
  • Français

Fabrication of Complex Hydrogel Materials by Utilizing Microfluidics and Micromolding

Published online by Cambridge University Press:  30 March 2012

Masumi Yamada ,
Sari Sugaya ,
Aoi Kobayashi ,
Ayaki Miyama ,
Yoji Naganuma ,
Emi Yamada ,
Shunta Kakegawa  and
Minoru Seki
Masumi Yamada
Affiliation:
Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, Chiba University, Chiba 263-8522, Japan.
Sari Sugaya
Affiliation:
Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, Chiba University, Chiba 263-8522, Japan.
Aoi Kobayashi
Affiliation:
Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, Chiba University, Chiba 263-8522, Japan.
Ayaki Miyama
Affiliation:
Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, Chiba University, Chiba 263-8522, Japan.
Yoji Naganuma
Affiliation:
Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, Chiba University, Chiba 263-8522, Japan.
Emi Yamada
Affiliation:
Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, Chiba University, Chiba 263-8522, Japan.
Shunta Kakegawa
Affiliation:
Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, Chiba University, Chiba 263-8522, Japan.
Minoru Seki
Affiliation:
Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, Chiba University, Chiba 263-8522, Japan.
Get access

Abstract

Here, we present microfluidic methods to fabricate complex hydrogel structures for 3D tissue or organ-like cell structures in vitro. First, a microfluidic system to continuously synthesize chemically and physically anisotropic Ca–alginate hydrogel microfibers is proposed to enable the guidance of cell proliferation and differentiation. Next, the microfluidic preparation methods for yarn-ball-shape hydrogel particles and extremely-small hydrogel microspheres. Finally, a newly developed micro-molding and bonding method for hydrogel micro-patterned plates is reported.

Keywords

fluidicsbiomaterialbiomimetic (assembly)
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1415: Symposium HH/II/TT – MEMS, BioMEMS and Bioelectronics–Materials and Devices , 2012 , mrsf11-1415-ii04-05
Copyright
Copyright © Materials Research Society 2012

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

[1]. Miyama, A., Yamada, M., Sugaya, S., and Seki, M., Proceedings of MicroTAS2011, edited by Landers, J. et al. ., (Seattle, WA, 2011) pp. 825–827.Google Scholar
[2]. Sugaya, S., Yamada, M., and Seki, M., Proceedings of MicroTAS2011, edited by Landers, J. et al. ., (Seattle, WA, 2011) pp. 18–20.Google Scholar
[3]. Yamada, E., Yamada, M., Iwase, M., Sugaya, S., and Seki, M., Proceedings of MicroTAS2011, edited by Landers, J. et al. ., (Seattle, WA, 2011) pp. 1834–1836.Google Scholar