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Endothelial Cell Adhesion on Highly Controllable Compared to Random Nanostructured Titanium Surface Features

Published online by Cambridge University Press:  01 February 2011

Jing Lu  and
Thomas J. Webster
Jing Lu
Affiliation:
[email protected], Brown University, Division of Engineering, 182, Hope Street, Providence, RI, 02912, United States
Thomas J. Webster
Affiliation:
[email protected], Brown University, Division of Engineering, 182, Hope Street, Providence, RI, 02912, United States
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Abstract

The application of vascular stents using conventional metals is limited because the implantation process will cause significant injury to the vascular wall and endothelium, resulting in neointima hyperplasia and then the development of long-term restenosis. The objective of this in vitro study was to investigate endothelial cell function (especially their adhesion behavior) on highly controllable nanostructured surface features. Considering the importance of the endothelium and its properties, highly controllable nanostructured surface features of titanium (a popular vascular stent metal) were created using E-beam evaporation to promote endothelialization and to control the direction of endothelial cells on vascular stents. Endothelial cells are aligned with blood flow naturally in the body. In this manner, the present in vitro study provides much promise for the use of nanotechnology for improving metals for vascular stent applications.

Keywords

nanostructurebiomaterialTi
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 951: Symposium E – Nanofunctional Materials, Nanostructures and Novel Devices for Biological and Chemical Detection , 2006 , 0951-E12-29
Copyright
Copyright © Materials Research Society 2007

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References

REFERENCES

1. National Institute of Health, 2005Google Scholar
2. Schuler, P, Assefa, D, Ylanne, J, et al. Adhesion of monocytes to medical steel as used for vascular stents is mediated by the integrin receptor Mac-1 (CD11b/CD18; alphaM beta2) and can be inhibited by semiconductor coating Cell Commun Adhes 2003; 10(1):17–26.Google Scholar
3. Cejuna, M, Virmani, R, Jones, R, et al. Biocompatibility and performance of the Wallstent and the Wallgraft, Jostent and Hemobahn stent-graft in a sheep model J Vasc Interv Radiol 2002; 13:823–30.Google Scholar
4. Chen, JY, Leng, YX, Tian, XB, et al. Antithrombogenic investigation of surface energy and optical bandgap and hemocompatibility mechanism of Ti(Ta(+5))O2 thin films, Biomaterials 2002; 23(12):2545–52.Google Scholar
5. Pitt, WG, Morris, RN, Mason, ML. Attachment of hyaluronan to metallic surfaces, J Biomed Mater Res 2004; 68(1):95–106.Google Scholar
6. Choudhary, S, Berhe, M, Haberstroh, KM and Webster, TJ. Increased endothelial and vascular smooth muscle cell adhesion on nanostructured titanium and CoCrMo International Journal of Nanomedicine 2006; 1(1): 41–49.Google Scholar
7. Khang, D, Sato, M, et al. Selective and mineral deposition by osteoblasts on carbon nanofiber patterns International Journal of Nanomedicine 2006; 1(1): 65–72.Google Scholar
8. Webster, TJ, Ejiofor, JU. Increased osteoblast adhesion on nanophase metals: Ti, Ti6A14V, CoCrMo Biomaterials 2004; 25 (19): 4731–4739.Google Scholar
9. Palmaz, C, Benson, A, Eugene, A. Influence of surface topography on endothelialization of intravascular metallic material J Vasc Interv Radiol 1999; 10(4):439–44.Google Scholar
10. Clark, P, Connolly, P, Curtis, ASG, Dow, JAT, Wilkinson, CDW. Cell guidance by ultrafine topography in vitro J Cell Sci 1991; 99:73–7.Google Scholar
11. Khakbaznejad, A, Chehroudi, B, Brunette, DM. Effects of titanium-coated micromachined grooved substrata on orienting layers of osteoblast-like cells and collagen fibers in culture J Biomed Mater Res 2004; 70(2):206–18.Google Scholar