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Electrochemical Hydroxyapatite Coatings on Nitinol Stents for the Reduction of Metal Ions Elution

Published online by Cambridge University Press:  14 January 2014

Daisuke Kondo ,
Tomohiko Yoshioka ,
Toshiyuki Ikoma ,
Kensuke Takamatsu ,
Kunihiro Ohta  and
Junzo Tanaka
Daisuke Kondo
Affiliation:
Department of Metallurgy and Ceramics Science, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan
Tomohiko Yoshioka
Affiliation:
Department of Metallurgy and Ceramics Science, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan
Toshiyuki Ikoma
Affiliation:
Department of Metallurgy and Ceramics Science, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan
Kensuke Takamatsu
Affiliation:
Tamachi Industries Co. Ltd., 4-10-2 Minami-ooi, Shinagawa-ku, Tokyo 140-0013, Japan
Kunihiro Ohta
Affiliation:
Tamachi Industries Co. Ltd., 4-10-2 Minami-ooi, Shinagawa-ku, Tokyo 140-0013, Japan
Junzo Tanaka
Affiliation:
Department of Metallurgy and Ceramics Science, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan
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Abstract

Nitinol was coated with biocompatible calcium phosphate materials by pulsed electrolytic deposition (ELD) to reduce toxic metal-ions elution. The pulse ELD for the stents was carried out with changing the current off-periods (toff) of the pulse wave. The pulse ELD suppressed the generation of H2 gas due to the electrolysis of water on a calcium phosphate layer and improved the adhesiveness of the coating layer on nitinol compared with a conventional DC-ELD. The coating layers were identified to be octacalcium phosphate (OCP) at lower toff, while they were transformed to dicalcium phosphate anhydraous (DCPA) with an increase of toff. The layers of OCP or DCPA on the nitinol surface were subjected to a NaOH treatment at 60°C for 3days to transform them into hydroxyapatite (HAp). From results of a metal-ions elution test, the deposited calcium phosphates suppressed nickel ions elution at one quarter compared with the bare nitinol stent. These results indicate that the pulse ELD of biocompatible calcium phosphate materials on the nitinol stent was one of the best techniques to create firmly attached coating on it and reduce toxic nickel ions elution.

Keywords

electrodepositionbiomaterialcoating
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1626: Symposium K – Adaptive Soft Matter through Molecular Networks , 2014 , mrsf13-1626-k08-15
Copyright
Copyright © Materials Research Society 2014 

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