Hostname: page-component-586b7cd67f-t7czq Total loading time: 0 Render date: 2024-12-01T02:20:45.175Z Has data issue: false hasContentIssue false
  • English
  • Français

Development of novel bioelectrocatalytic platform based on in situ generated gold nanoparticles for biomedical applications

Published online by Cambridge University Press:  06 March 2012

Prem C. Pandey  and
Dheeraj S. Chauhan
Prem C. Pandey
Affiliation:
Department of Applied Chemistry, Institute of Technology, Banaras Hindu University, Varanasi- 221005, India.
Dheeraj S. Chauhan
Affiliation:
Department of Applied Chemistry, Institute of Technology, Banaras Hindu University, Varanasi- 221005, India.
Get access

Abstract

Gold nanoparticles (AuNp) formed using alkoxysilane precursors are utilized in the development of thin organically modified silicates (ormosil) films. The resulting films are optically transparent thereby retaining the optical properties of AuNp. Surface morphology shows that the in situ generated AuNp retained their nanogeometry in the ormosil films. An application of the AuNp encapsulated ormosils is shown in electrocatalytic determination of hydrogen peroxide. For this purpose, potassium ferricyanide is chosen as electron transfer mediator and is encapsulated in the films. Results show that the presence of AuNp in the ormosil matrix dramatically improves the electrochemical behavior of potassium ferricyanide. The ormosil films are utilized for electrocatalytic determination of hydrogen peroxide. In order to investigate the biocompatibility of the ormosil film, horseradish peroxidase (HRP) is incorporated resulting in improvement in oxidation and reduction of peroxide.

Keywords

sensorcatalyticnanostructure
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1418: Symposium LL/MM – Gels and Biomedical Materials , 2012 , mrsf11-1418-mm11-10
Copyright
Copyright © Materials Research Society 2012

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1. Cui, H., Zhang, Z. -F. and Shi, M. –J., J. Phys. Chem. B 109, 3099 (2005).CrossRefGoogle Scholar
2. Dass, A., Guo, R., Tracy, J. B., Balasubramanian, R., Douglas, A. D. and Murray, R. W., Langmuir 24, 310 (2008).CrossRefGoogle Scholar
3. Cho, S. –J., Idrobo, J. –C., Olamit, J., Liu, K., Browning, N. D. and Kauzlarich, S. M., Chem. Mater. 17, 3181 (2005).CrossRefGoogle Scholar
4. Rahman, M. A., Son, J. I., Won, M. –S. and Shim, Y. –B., Anal. Chem. 81, 6604, (2009).CrossRefGoogle Scholar
5. Guo, R., Wang, H., Peng, C., Shen, M., Pan, M., Cao, X., Zhang, G. and Shi, X., J. Phys. Chem. C 114, 50 (2010).CrossRefGoogle Scholar
6. Isaacs, S. R., Cutler, E. C., Park, J. –S., Lee, T. R. and Shon, Y. –S., Langmuir 21, 5689 (2005).CrossRefGoogle Scholar
7. Maduraiveeran, G. and Ramaraj, R., J. Electroanal. Chem. 608, 52 (2007).CrossRefGoogle Scholar
8. Pandey, P. C., Chauhan, D. S. and Singh, V., Mat. Sci. Eng. C 32, 1 (2012).CrossRefGoogle Scholar
9. Pandey, P. C. and Chauhan, D. S., A Process For In situ Generation of Noble Metal Nanoparticles and thereafter Core Shell of the same, Indian Patents 2382/ DEL/2010.Google Scholar
10. de Mattos, L., Gorton, L. and Ruzgas, T., Biosens. Bioelectron. 18, 193 (2003).CrossRefGoogle Scholar
11. Moscone, D., D’Ottavi, D., Compagnone, D., Palleschi, G. and Amine, A., Anal. Chem. 73, 2529 (2001).CrossRefGoogle Scholar
12. Lukachova, L. V., Kotel’nikova, E. A., D’Ottavi, D., Shkerin, E. A., Karyakina, E. E., Palleschi, G., Curulli, A. and Karyakin, A. A., Bioelectrochemistry 55, 145 (2002).CrossRefGoogle Scholar
13. Karyakin, A. A., Electroanalysis 13, 813 (2001).3.0.CO;2-Z>CrossRefGoogle Scholar
14. Karyakin, A. A., Karyakina, E. E. and Gorton, L., Anal. Chem. 72, 1720 (2000).CrossRefGoogle Scholar
15. Wang, G., Zhou, J. and Li, J., Biosens. Bioelectron. 22, 2921 (2007).CrossRefGoogle Scholar
16. Haghighi, B., Hamidi, H. and Gorton, Lo, Sens. Actuators B 147, 270 (2010).CrossRefGoogle Scholar