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Collagenous Biocomposites for the Repair of Soft Tissue Injury

Published online by Cambridge University Press:  15 February 2011

David Christiansen ,
George Pins ,
Ming Che Wang ,
Michael G. Dunn  and
Frederick H. Silver
David Christiansen
Affiliation:
Dept. of Pathology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ. 08854
George Pins
Affiliation:
Dept. of Pathology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ. 08854
Ming Che Wang
Affiliation:
Dept. of Pathology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ. 08854
Michael G. Dunn
Affiliation:
Orthopaedic Research Laboratory, Division of Orthopaedic Surgery, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ 08903
Frederick H. Silver
Affiliation:
Dept. of Pathology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ. 08854
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Abstract

Results of implantation studies in a variety of animal tissue models demonstrate that the rate of biogradation of a collagen scaffold should parallel the rate of wound healing observed in particular anatomic sites. This rapid degradation maximizes tissue regeneration and minimizes encapsulation of the implant. The following paper reviews the effects of crosslinking on the rate of tissue ingrowth and regeneration. In addition, preliminary mechanical data on newly developed soluble type I collagen fibers is presented as a possible advance in the production of high strength collagen based tissue scaffolds.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 252: Symposium T – Tissue-Inducing Biomaterials , 1991 , 151
Copyright
Copyright © Materials Research Society 1992

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References

REFERENCES

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