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Closed loop microfluidic platform based on domain wall magnetic conduits: a novel tool for biology and medicine

Published online by Cambridge University Press:  21 November 2014

M. Monticelli ,
D. Petti ,
E. Albisetti ,
M. Cantoni ,
E. Guerriero ,
R. Sordan ,
M.Carminati ,
G. Ferrari ,
M. Sampietro  and
R. Bertacco
M. Monticelli
Affiliation:
CNISM and LNESS - Politecnico di Milano, Via Anzani 42, 22100 Como, Italy
D. Petti
Affiliation:
CNISM and LNESS - Politecnico di Milano, Via Anzani 42, 22100 Como, Italy
E. Albisetti
Affiliation:
CNISM and LNESS - Politecnico di Milano, Via Anzani 42, 22100 Como, Italy
M. Cantoni
Affiliation:
CNISM and LNESS - Politecnico di Milano, Via Anzani 42, 22100 Como, Italy
E. Guerriero
Affiliation:
CNISM and LNESS - Politecnico di Milano, Via Anzani 42, 22100 Como, Italy
R. Sordan
Affiliation:
CNISM and LNESS - Politecnico di Milano, Via Anzani 42, 22100 Como, Italy
M.Carminati
Affiliation:
Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, P.zza L. Da Vinci 32, 20131 Milano, Italy
G. Ferrari
Affiliation:
Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, P.zza L. Da Vinci 32, 20131 Milano, Italy
M. Sampietro
Affiliation:
Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, P.zza L. Da Vinci 32, 20131 Milano, Italy
R. Bertacco
Affiliation:
CNISM and LNESS - Politecnico di Milano, Via Anzani 42, 22100 Como, Italy
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Abstract

In this paper we present an innovative on-chip platform suitable for the simultaneous manipulation and detection of the transit of a single magnetic bead. This system is based on the controlled displacement of constrained magnetic domain walls (DWs) that are used to move and sense particles in suspension over the chip. To this scope, the high stray field from the transverse DWs created at the corners of ferromagnetic zig-zag structures is used for particles manipulation, while electrical contacts flanking a single corner are employed to simultaneously monitor the DW passage through that corner, via anisotropic magneto resistance (AMR) measurements. A single DW carrying a magnetic particle is nucleated and manipulated within the zig-zag shaped magnetic conduit, trough the action of external magnetic fields. At the same time, the variation of the voltage drop across a corner flanked by a pair of electrical leads is measured, allowing to detect the transit of the DW thanks to the change of the relative orientation of current and spins at the corner related to the peculiar micromagnetic configuration of the DW (AMR). Work is in progress in order to selectively distinguish the transit of a naked DW from that of a DW bound to a magnetic particle. This work paves the way to the development of a closed-loop microlfuidic platform for on-chip bead manipulation, where single bead can be finely moved and their motion continuously checked, via AMR electrical detection and without need of optical monitoring, in a fully integrated closed-loop system.

Keywords

magnetoresistance (magnetic)nanostructuremagnetoresistance (transport)
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1686: Symposium V – Micro- and Nanofluidic Systems for Materials Synthesis, Device Assembly and Bioanalysis , 2014 , mrss14-1686-v02-06
Copyright
Copyright © Materials Research Society 2014 

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