Hostname: page-component-586b7cd67f-t7fkt Total loading time: 0 Render date: 2024-11-28T14:32:27.534Z Has data issue: false hasContentIssue false
  • English
  • Français

Blood Compatibility of Stainless-Steel and Titanium Immobilized with Alginic Acid Layers

Published online by Cambridge University Press:  11 February 2011

Tomohiko Yoshioka ,
Kanji Tsuru ,
Satoshi Hayakawa  and
Akiyoshi Osaka
Tomohiko Yoshioka
Affiliation:
Biomaterials Laboratory, Faculty of Engineering, Okayama University Tsushima, Okayama, 700–8530, Japan.
Kanji Tsuru
Affiliation:
Biomaterials Laboratory, Faculty of Engineering, Okayama University Tsushima, Okayama, 700–8530, Japan.
Satoshi Hayakawa
Affiliation:
Biomaterials Laboratory, Faculty of Engineering, Okayama University Tsushima, Okayama, 700–8530, Japan.
Akiyoshi Osaka
Affiliation:
Biomaterials Laboratory, Faculty of Engineering, Okayama University Tsushima, Okayama, 700–8530, Japan.
Get access

Abstract

γ-Aminopropyltriethoxysilane (γ-APS) was grafted on stainless-steel and titanium substrates, and subsequently alginic acid layer was immobilized on them. Their surfaces were characterized with X-ray photoelectron spectroscopy (XPS) and contact angle measurement. Blood compatibility of thus obtained substrates was evaluated in terms of both the number of the adhered platelets and blood clotting factors for plasma contacted with the substrates such as active partial thromboplastin time (PTT), prothrombin time (PT), and amount of fibrinogen (Fib). The steel and titanium substrates with alginic acid layer did not affect blood clotting factors. In vitro platelet adhesion assay indicated that those substrates adhered less number of platelets than non-treated substrates. Hence the alginic acid immobilization leads to blood compatible surfaces.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 734: Symposia A/B – Defect-Mediated Phenomena in Ordered Polymers – Polymer/Metal Interfaces and Defect Mediated Phenomena in Ordered Polymers , 2002 , B9.48
Copyright
Copyright © Materials Research Society 2003

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1. Windecker, S., Mayer, I., Pasquale, G. D., Maier, W., Dirsch, O., Groot, P. D., Wu, Y. P., Noll, G., Leskosek, B., Meier, B., and Hess, O. M., Circulation 104, 928 (2001).CrossRefGoogle Scholar
2. Takemoto, S., Tsuru, K., Hayakawa, S., Osaka, A., and Takashima, S., J. Sol-Gel Sci. Technol. 21, 97 (2001).CrossRefGoogle Scholar
3. Morra, M., and Cassinelli, C., Surf. Interface Anal. 26, 742 (1998).3.0.CO;2-P>CrossRefGoogle Scholar
4. Morra, M., and Cassinelli, C., Langmuir 15, 4658 (1999).CrossRefGoogle Scholar
5. Morra, M., and Cassinelli, C., J. Biomater. Sci. Polymer Edn. 10(10), 1107 (1999).CrossRefGoogle Scholar
6. Morra, M., and Cassinelli, C., Colloids Surf. B Biointerfaces. 18, 249 (2000).CrossRefGoogle Scholar
7. Hayakawa, S., Osaka, A., Nishioka, H., Matsumoto, S., and Miura, Y., J. Non-Cryst. Solids 272, 103 (2000).CrossRefGoogle Scholar
8. Endo, K., Dent. Mater. J. 14(2), 199 (1995).CrossRefGoogle Scholar
9. Lin, J. C., and Chuang, W. H., J. Biomed. Mater. Res. 51, 413 (2000).3.0.CO;2-L>CrossRefGoogle Scholar
10. Lestelius, M., Liedberg, B., and Tengvall, P., Langmuir 13, 5900 (1997).CrossRefGoogle Scholar