Hostname: page-component-586b7cd67f-t7czq Total loading time: 0 Render date: 2024-11-24T09:59:25.869Z Has data issue: false hasContentIssue false
  • English
  • Français

Bioinspired Artificial Protein Materials: Self-Assembly and Order from Nano to Macroscale

Published online by Cambridge University Press:  10 March 2011

Min Dai ,
Jennifer S. Haghpanah ,
Carlo Yuvienco  and
Jin Kim Montclare
Min Dai
Affiliation:
Polytechnic Institute of New York University, 6 Metrotech Center, Brooklyn, NY, 11201 U.S.A.
Jennifer S. Haghpanah
Affiliation:
Polytechnic Institute of New York University, 6 Metrotech Center, Brooklyn, NY, 11201 U.S.A.
Carlo Yuvienco
Affiliation:
Polytechnic Institute of New York University, 6 Metrotech Center, Brooklyn, NY, 11201 U.S.A.
Jin Kim Montclare
Affiliation:
Polytechnic Institute of New York University, 6 Metrotech Center, Brooklyn, NY, 11201 U.S.A. SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, U.S.A.
Get access

Abstract

We describe the biosynthesis and characterization of protein materials comprised of two distinct self-assembling domains (SADs): elastin (E) found in tissue for its elastic properties and cartilage oligomeric matrix protein coiled-coil (COMPcc, C) predominantly locatedin joint and in bones. Based on earlier studies on protein block polymers comprised these two SADs, orientation and number of blocks play a crucial role in the overall stimuli-responsive supramolecular assembly behavior. Here we fabricate a range of EnC and CEn block polymers in which the E domain is systematically truncated to explore the effects of the E domain on the overall physicochemical behavior.

Keywords

biomaterialbiological synthesis (assembly)biomimetic (assembly)
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1301: Symposium V/NN/OO/PP – Soft Matter, Biological Materials and Biomedical Materials—Synthesis, Characterization and Applications , 2011 , mrsf10-1301-oo11-04
Copyright
Copyright © Materials Research Society 2011

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1. Channon, K.J., Devlin, G.L., and MacPhee, C.E., Journal of the American Chemical Society, 2009. 131, 12520–12521.Google Scholar
2. John, G. and Vemula, P.K., Soft Matter, 2006. 2(11): p. 909–914.Google Scholar
3. Kopecek, J., Journal of Polymer Science Part a-Polymer Chemistry, 2009. 47(22): p. 5929–5946.Google Scholar
4. Ma, H., Zin, M.T., Zareie, M.H., Kang, M.S., Kang, S.H., Kim, K.S., Reed, B.W., Behar, C.T., Sarikaya, M., and Jen, A.K.Y., Journal of Nanoscience and Nanotechnology, 2007. 7(8): p. 2549–2566.Google Scholar
5. Marquis, B.J., Love, S.A., Braun, K.L., and Haynes, C.L., Analyst, 2009. 134(3): p. 425–439.Google Scholar
6. Shen, X.C., Mo, X.Q., Moore, R., Frazier, S.J., Iwamoto, T., Tomich, J.M., and Sun, X.Z.S., Journal of Nanoscience and Nanotechnology, 2006. 6(3): p. 837–844.Google Scholar
7. Banerjee, I.A., Muniz, G., Lee, S.Y., and Matsui, H., Journal of Nanoscience and Nanotechnology, 2007. 7(7): p. 2287–2292.Google Scholar
8. Banerjee, I.A., Yu, L.T., and Matsui, H., Proceedings of the National Academy of Sciences of the United States of America, 2003. 100(25): p. 14678–14682.Google Scholar
9. Banerjee, I.A., Yu, L.T., and Matsui, H., Journal of the American Chemical Society, 2005. 127(46): p. 16002–16003.Google Scholar
10. Connor, R.E. and Tirrell, D.A., Polymer Reviews, 2007. 47(1): p. 9–28.Google Scholar
11. Voloshchuk, N.. and Montclare, J.K.,. Mol BioSys, 2010. 6: p. 65–80.Google Scholar
12. Haghpanah, J.S., Yuvienco, C., Civay, D.E., Barra, H., Baker, P.J., Khapli, S., Voloshchuk, N., Gunasekar, S.K., Muthukumar, M., and Montclare, J.K., ChemBioChem, 2009. 10(17): p. 2733–5.Google Scholar
13. Haghpanah, J.S., Yuvienco, C., Roth, E., Liang, A., Tu, R.S., and Montclare, J.K., Molecular BioSystems, 2010. 6: p. 1662–1667.Google Scholar
14. Aathimanikandan, S.V., Savariar, E.N., and Thayumanavan, S.,. Journal of the American Chemical Society, 2005. 127(42): p. 14922–14929.Google Scholar
15. Klaikherd, A., Nagamani, C., and Thayumanavan, S., Journal of the American Chemical Society, 2009. 131(13): p. 4830–4838.Google Scholar
16. Arvinte, T., Bui, T.T.T., Dahab, A.A., Demeule, B., Drake, A.F., Elhag, D., and King, P., Analytical Biochemistry, 2004. 332(1): p. 46–57.Google Scholar