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UV-initiated crosslinking of electrospun chitosan/poly(ethylene oxide) nanofibers doped with ZnO-nanoparticles: development of antibacterial nanofibrous hydrogel

Published online by Cambridge University Press:  30 September 2020

G.M. Estrada-Villegas ,
J.I. Del Río-De Vicente ,
L. Argueta-Figueroa  and
G. González-Pérez
G.M. Estrada-Villegas*
Affiliation:
CONACyT — Centro de Investigación en Química Aplicada, Av. Alianza Sur 204 Parque de Innovación e Investigación Tecnológica, Apodaca, Nuevo León66629, Mexico
J.I. Del Río-De Vicente
Affiliation:
CONACyT — Centro de Investigación en Química Aplicada, Av. Alianza Sur 204 Parque de Innovación e Investigación Tecnológica, Apodaca, Nuevo León66629, Mexico
L. Argueta-Figueroa
Affiliation:
CONACyT — Facultad de Odontología, Universidad Autónoma Benito Juárez de Oaxaca, Oaxaca68120, Mexico
G. González-Pérez
Affiliation:
Departamento de Ingeniería, Tecnológico Nacional de México, Instituto Tecnológico de Nuevo León, Av. Eloy Cavazos, # 2001 Colonia Tolteca, Guadalupe, Nuevo León67170, Mexico
*
Address all correspondence to G.M. Estrada-Villegas at [email protected]
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Abstract

UV-initiated crosslinking of electrospun poly(ethylene) oxide (PEO)/chitosan (CS) nanofibers doped with zinc oxide nanoparticles (ZnO-NPs) was performed using pentaerythritol triaclyrate (PETA) as the photoinitiator and crosslinker agent. The influence of the addition of PETA to the PEO/CS diameter and crosslinking of nanofibers was evaluated. The effect of irradiation time on the morphology and swelling properties of the crosslinked nanofibers were investigated. For ZnO-NPs, the minimum inhibitory concentrations were found at 1 mg/mL, and the minimum bactericidal concentrations at 2 mg/mL for all the strains tested. The nanofibrous hydrogel antibacterial effect was tested. This material enters the realm of fibrous hydrogels which have potential use in several applications as in the biomedical area.

Type
Research Letters
Information
MRS Communications , Volume 10 , Issue 4 , December 2020 , pp. 642 - 651
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Copyright
Copyright © The Author(s), 2020, published on behalf of Materials Research Society by Cambridge University Press

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