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Coupling synthetic biology and programmable materials to construct complex tissue ecosystems

Published online by Cambridge University Press:  27 May 2019

Catherine S. Millar-Haskell ,
Allyson M. Dang  and
Jason P. Gleghorn
Catherine S. Millar-Haskell
Affiliation:
Departments of Biomedical Engineering, University of Delaware, Newark, DE 19716, USA
Allyson M. Dang
Affiliation:
Departments of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA
Jason P. Gleghorn*
Affiliation:
Departments of Biomedical Engineering, University of Delaware, Newark, DE 19716, USA
*
Address all correspondence to Jason P. Gleghorn at [email protected]
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Abstract

Synthetic biology combines engineering and biology to produce artificial systems with programmable features. Specifically, engineered microenvironments have advanced immensely over the past few decades, owing in part to the merging of materials with biologic mimetic structures. In this review, the authors adapt a traditional definition of community ecology to describe “cellular ecology,” or the study of the distribution of cell populations and interactions within their microenvironment. The authors discuss two exemplar hydrogel platforms: (1) self-assembling peptide hydrogels and (2) poly(ethylene) glycol hydrogels and describe future opportunities for merging smart material design and synthetic biology within the scope of multicellular platforms.

Type
Synthetic Biology Prospective
Information
MRS Communications , Volume 9 , Issue 2 , June 2019 , pp. 421 - 432
Copyright
Copyright © Materials Research Society 2019 

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