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Shape and Biomechanical Characteristics of Human Red Blood Cells in Health and Disease

Published online by Cambridge University Press:  31 January 2011

Monica Diez-Silva ,
Ming Dao ,
Jongyoon Han ,
Chwee-Teck Lim  and
Subra Suresh
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Abstract

The biconcave shape and corresponding deformability of the human red blood cell (RBC) is an essential feature of its biological function. This feature of RBCs can be critically affected by genetic or acquired pathological conditions. In this review, we highlight new dynamic in vitro assays that explore various hereditary blood disorders and parasitic infectious diseases that cause disruption of RBC morphology and mechanics. In particular, recent advances in high-throughput microfluidic devices make it possible to sort/identify healthy and pathological human RBCs with different mechanobiological characteristics.

Type
Research Article
Information
MRS Bulletin , Volume 35 , Issue 5: In Situ Mechanical Testing of Biological and Inorganic Materials at the Micro- and Nanoscales , May 2010 , pp. 382 - 388
Copyright
Copyright © Materials Research Society 2010

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References

1.Fung, Y.C., Biomechanics: Mechanical Properties of Living Tissues (Springer-Verlag, New York, 1993).CrossRefGoogle Scholar
2.Tse, W.T., Lux, S.E. Br., J. Haematol. 104, 2 (1999).CrossRefGoogle Scholar
3.Li, J., Dao, M., Lim, C.T., Suresh, S., Biophys. J. 88, 3707 (2005).CrossRefGoogle Scholar
4.Lim, H.W.G., Wortis, M., Mukhopadhyay, R., Proc. Nat. Acad. Sci. U.S.A. 99, 16766 (2002).CrossRefGoogle Scholar
5.Canham, P.B., J. Theor. Biol. 26, 61 (1970).CrossRefGoogle Scholar
6.Helfrich, W., Z. Naturforsch., C: Biosci. C 28, 693 (1973).CrossRefGoogle Scholar
7.Discher, D.E., Boal, D.H., Boey, S.K., Phys. Rev. E 55, 4762 (1997).CrossRefGoogle Scholar
8.Discher, D.E., Boal, D.H., Boey, S.K., Biophys. J. 75, 1584 (1998).CrossRefGoogle Scholar
9.Li, J., Lykotrafitis, G., Dao, M., Suresh, S., Proc. Nat. Acad. Sci. U.S.A. 104, 4937 (2007).CrossRefGoogle Scholar
10.Wong, P., J. Theor. Biol. 196, 343 (1999).CrossRefGoogle Scholar
11.Gov, N.S., Safran, S.A., Biophys. J. 88, 1859 (2005).CrossRefGoogle Scholar
12.Park, Y.K., Best, C.A., Auth, T., Gov, N., Safran, G., Popescu, G., Suresh, S., Feld, M.S., Proc. Nat. Acad. Sci. U.S.A. 107, 1289 (2010).Google Scholar
13.Eber, S., Lux, S.E., Semin. Hematol. 41, 118 (2004).CrossRefGoogle Scholar
14.Perrotta, S., Gallagher, P.G., Mohandas, N., Lancet 372, 1411 (2008).CrossRefGoogle Scholar
15.Gallagher, P.G., Curr. Hematol. Rep. 3, 85 (2004).Google Scholar
16.Becker, P.S., Lux, S.E., Clin. Haematol. 14, 15 (1985).Google Scholar
17.Liu, S.C., Derick, L.H., Agre, P., Palek, J., Blood 76, 198 (1990).Google Scholar
18.Da Costa, L., Mohandas, N., Sorette, M., Grange, M.J., Tchernia, G., Cynober, T., Blood 98, 2894 (2001).CrossRefGoogle Scholar
19.Walensky, L.D., Narla, M., Lux, S.E., in Blood: Principles and Practice of Hematology, 2nd Edition, Handin, R.I., Lux, S.E., Stossel, T.P., Eds. (Lippincott Williams, and Wilkins, Philadelphia, 2003), p. 1709.Google Scholar
20.Pauling, L., Itano, H.A., Singer, S.J., Wells, I.C., Science 110, 543 (1949).Google Scholar
21.Ingram, V.M., Nature 178, 792 (1956).CrossRefGoogle Scholar
22.Embury, S.H., Hebbel, R.P., Steinberg, M.H., Mohandas, N., in Sickle Cell Disease, Embury, S.H., Hebbel, R.P., Mohandas, N., Steinberg, M.H., Eds. (Raven Press, New York, 1994), p. 311.Google Scholar
23.Mohandas, N., Hebbel, R.P., in Sickle Cell Disease, Embury, S.H., Hebbel, R.P., Mohandas, N., Steinberg, M.H., Eds. (Raven Press, New York 1994), p. 205.Google Scholar
24.Hebbel, R.P., Yamada, O., Moldow, C.F., Jacob, H.S., White, J.G., Eaton, J.W., J. Clin. Invest. 65, 154 (1980).CrossRefGoogle Scholar
25.Higgins, J.M., Eddington, D.T., Bhatia, S.N., Mahadevan, L., Proc. Nat. Acad. Sci. U.S.A. 104, 20496 (2007).Google Scholar
26.Hill, A.V.S., Allsopp, C.E.M., Kwiatkowski, D., Anstey, N.M., Twumasi, P., Rowe, P.A., Bennett, S., Brewster, D., McMichael, A.J., Greenwood, B.M., Nature 352, 595 (1991).Google Scholar
27.Greenwood, A., Mutabingwa, B., Malaria, T., Nature 415, 670 (2002).CrossRefGoogle Scholar
28.Mills, J.P., Diez-Silva, M., Quinn, D.J., Dao, M., Lang, M.J., Tan, K.S.W., Lim, C.T., Milon, G., David, P.H., Mercereau-Puijalon, O., Bonnefoy, S., Suresh, S., Proc. Nat. Acad. Sci. U.S.A. 104, 9213 (2007).Google Scholar
29.Glenister, F.K., Coppel, R.L., Cowman, A.F., Mohandas, N., Cooke, B.M., Blood 99, 1060 (2002).CrossRefGoogle ScholarPubMed
30.Glenister, F.K., Fernandez, K.M., Kats, L.M., Hanssen, E., Mohandas, N., Coppel, R.L., Cooke, B.M., Blood 113, 919 (2009).CrossRefGoogle ScholarPubMed
31.Cranston, H.A., Boylan, C.W., Carroll, G.L., Sutera, S.P., Williamson, J.R., Gluzman, I.Y., Krogstad, D.J., Science 223, 400 (1984).CrossRefGoogle Scholar
32.Dondorp, A.M., Angus, B.J., Hardeman, M.R., Chotivanich, K.T., Silamut, K., Ruangveerayuth, R., Kager, P.A., White, N.J., Vreeken, J., Am. J. Trop. Med. Hyg. 57, 507 (1997).CrossRefGoogle Scholar
33.Paulitschke, M., Nash, G.B., J. Lab. Clin. Med. 122, 581 (1993).Google Scholar
34.Suresh, S., Spatz, J., Mills, J.P., Micoulet, A., Dao, M., Lim, C.T., Beil, M., Seufferlein, T., Acta Biomater. 1, 15 (2005).CrossRefGoogle Scholar
35.Mills, J.P., Qie, L., Dao, M., Tan, K.S.W., Lim, C.T., Suresh, S., in Mechanical Properties of Bioinspired and Biological Materials, Viney, C., Katti, K., Ulm, F.J., Hellmich, C., Eds. (2005), 844, p. 179.Google Scholar
36.Park, Y.K., Diez-Silva, M., Popescu, G., Lykotrafitis, G., Choi, W.S., Feld, M.S., Suresh, S., Proc. Nat. Acad. Sci. U.S.A. 105, 13730 (2008).CrossRefGoogle Scholar
37.Bao, G., Suresh, S., Nat. Mater. 2, 715 (2003).CrossRefGoogle Scholar
38.Van Vliet, K.J., Li, J., Zhu, T., Yip, S., Suresh, S., Phys. Rev. B 67, (2003).Google Scholar
39.Shelby, J.P., White, J., Ganesan, K., Rathod, P.K., Chiu, D.T., Proc. Nat. Acad. Sci. U.S.A. 100, 14618 (2003).CrossRefGoogle Scholar
40.Antia, M., Herricks, T., Rathod, P.K., PLoS Pathog. 3, 939 (2007).CrossRefGoogle Scholar
41.Herricks, T., Antia, M., Rathod, P.K., Cell. Microbiol. 11, 1340 (2009).Google Scholar
42.Handayani, S., Chiu, D.T., Tjitra, E., Kuo, J.S., Lampah, D., Kenangalem, E., Renia, L., Snounou, G., Price, R.N., Anstey, N.M., Russell, B., Journal of Infectious Diseases 199, 445 (2009).Google Scholar
43.Safeukui, I., Correas, J.M., Brousse, V., Hirt, D., Deplaine, G., Mule, S., Lesurtel, M., Goasguen, N., Sauvanet, A., Couvelard, A., Kerneis, S., Khun, H., Vigan-Womas, I., Ottone, C., Molina, T.J., Treluyer, J.M., Mercereau-Puijalon, O., Milon, G., David, P.H., Buffet, P.A., Blood 112, 2520 (2008).Google Scholar
44.Udeinya, I.J., Schmidt, J.A., Aikawa, M., Miller, L.H., Green, I., Science 213, 555 (1981).CrossRefGoogle Scholar
45.Ockenhouse, C.F., Tandon, N.N., Magowan, C., Jamieson, G.A., Chulay, J.D., Science 243, 1469 (1989).Google Scholar
46.Roberts, D.D., Sherwood, J.A., Spitalnik, S.L., Panton, L.J., Howard, R.J., Dixit, V.M., Frazier, W.A., Miller, L.H., Ginsburg, V., Nature 318, 64 (1985).Google Scholar
47.Berendt, A.R., Simmons, D.L., Tansey, J., Newbold, C.I., Marsh, K., Nature 341, 57 (1989).Google Scholar
48.Oquendo, P., Hundt, E., Lawler, J., Seed, B., Cell 58, 95 (1989).Google Scholar
49.Baruch, D.I., Gormley, J.A., Ma, C., Howard, R.J., Pasloske, B.L., Proc. Nat. Acad. Sci. U.S.A. 93, 3497 (1996).Google Scholar
50.Rowe, J.A., Moulds, J.M., Newbold, C.I., Miller, L.H., Nature 388, 292 (1997).CrossRefGoogle Scholar
51.Cooke, B.M., Berendt, A.R., Craig, A.G., Macgregor, J., Newbold, C.I., Nash, G.B. Br., J. Haematol. 87, 162 (1994).CrossRefGoogle Scholar
52.Yipp, B.G., Anand, S., Schollaardt, T., Patel, K.D., Looareesuwan, S., Ho, M., Blood 96, 2292 (2000).Google Scholar
53.Gray, C., McCormick, C., Turner, G., Craig, A., Mol. Biochem. Parasitol. 128, 187 (2003).CrossRefGoogle Scholar
54.Cooke, B.M., Glenister, F.K., Mohandas, N., Coppel, R.L. Br., J. Haematol. 117, 203 (2002).Google Scholar
55.Antia, M., Herricks, T., Rathod, P.K., Cell. Microbiol. 10, 1968 (2008).CrossRefGoogle Scholar
56.Brody, J.P., Han, Y., Austin, R.H., Bitensky, M., Biophys. J. 68, 2224 (1995).Google Scholar
57.Davis, J.A., Inglis, D.W., Morton, K.J., Lawrence, D.A., Huang, L.R., Chou, S.Y., Sturm, J.C., Austin, R.H., Proc. Nat. Acad. Sci. U.S.A. 103, 14779 (2006).Google Scholar
58.Takagi, J., Yamada, M., Yasuda, M., Seki, M., Lab Chip 5, 778 (2005).CrossRefGoogle Scholar
59.Di Carlo, D., Edd, J.F., Irimia, D., Tompkins, R.G., Toner, M., Anal. Chem. 80, 2204 (2008).CrossRefGoogle Scholar
60.Shevkoplyas, S.S., Yoshida, T., Munn, L.L., Bitensky, M.W., Anal. Chem. 77, 933 (2005).CrossRefGoogle Scholar
61.Bow, H., Hou, H.W., Goldfless, S., Abgrall, P., Tan, K.S.W., Niles, J., Lim, C.T., Han, J., Proceedings of the MicroTAS 2009 conference, Jeju, Korea, pp. 1219 (2009).Google Scholar
62.Suresh, S., J. Mater. Res. 21 (8), 1871 (2006).CrossRefGoogle Scholar