Hostname: page-component-78c5997874-j824f Total loading time: 0 Render date: 2024-11-05T08:10:32.183Z Has data issue: false hasContentIssue false
  • English
  • Français

Nanotechnology and Related Safety Issues for Delivery of Active Ingredients in Cosmetics

Published online by Cambridge University Press:  31 January 2011

P. Somasundaran ,
Somil C. Mehta ,
Linda Rhein  and
Soma Chakraborty
Get access

Abstract

Nature exhibits a variety of remarkable phenomena that are useful but difficult to imitate in real life. Examples are the “touch me not” plant (Mimosa pudica), which folds up upon being attacked, or microbes that deposit on ocean vessels even under hostile conditions. Understanding the mechanisms governing these phenomena can prove powerful for developing new classes of cosmetic products. This article examines the development of novel materials with functional properties such as controlled delivery and the deposition of sensory attributes (fragrances, flavors, etc.) desirable in cosmetic products. Particularly, systems based on polymer/surfactant chemistry are explored for achieving transport and release of cosmetic and pharmaceutical molecules at desired rates. The hybrid polymers and nanogel particle systems discussed here represent new classes of materials with nanodomains that can be tuned to extract and deliver cosmetic attributes by means of changes in natural parameters such as temperature and pH. While the safety of existing nanomaterials marketed for decades has not been an issue, methods are urgently needed to validate the toxicological safety of future nanomaterials.

Type
Research Article
Information
MRS Bulletin , Volume 32 , Issue 10: The Materials Science of Cosmetics , October 2007 , pp. 779 - 786
Copyright
Copyright © Materials Research Society 2007

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Normand, V., Avison, S., Parker, A., Chem. Senses 29, 235 (2004).CrossRefGoogle Scholar
2.Quellet, C., Schudel, M., Ringgenberg, R., Chimia 55, 421 (2001).Google Scholar
3.Ouali, L., Latreche, D., “Polymeric Particles and Fragrance Delivery Systems,” Eur. Patent EP 1443058 (August 4, 2004).Google Scholar
4.Somasundaran, P., Chakraborty, S., “Preparation of Polymeric Nanoparticles and Nanogels for Extraction and Release of Fragrance and Bioactive Molecules,” Int. Patent WO 2006052285 (May 18, 2006).Google Scholar
5.Wissing, S.A., Müller, R.H., Int. J. Pharm. 254, 65 (2003).Google Scholar
6.Mathiowitz, E., Kreitz, M., Brannon-Peppas, L., Encyclopedia of Controlled Drug Delivery (Wiley, New York, 1999).Google Scholar
7.Baek, N., Park, K., Reflexive Polymers and Hydrogels, 85 (2004).Google Scholar
8.Lundquist, E.G., Devonport, W., Will, J.P., “Poly meric Nanoparticles in Consumer Products,” Eur. Patent EP 1447074 (August 18, 2004).Google Scholar
9.Guzman, M., Molpeceres, J., Garcia, F., Aberturas, M.R., Rodriguez, M., J. Pharm. Sci. 82 (5), 498 (1993).CrossRefGoogle Scholar
10.Mizushima, H., Kaneko, K., Ozeki, Y., “Manufacture of Drug-Encapsulated Nano parti cles,” Jpn. Kokai Tokkyo Koho, JP 2006131577 (2006).Google Scholar
11.Dupeyron, D., Gonzalez, M., Saez, V., Ramon, J., Rieumont, J., IEE Proc. Nanobiotechnol. 152 (5), 165 (2005).CrossRefGoogle Scholar
12.Muzykantov, V.R., Dziubla, T., “Antioxidant Polymer Nanocarriers for Use in Preventing Oxidative Injury,” U.S. Patent Appl. 20060127386 (June 15, 2006).Google Scholar
13.Somasundaran, P., Mehta, S.C., Purohit, P., Adv. Colloid Interface Sci. 128–130, 103 (2006).CrossRefGoogle Scholar
14.Somasundaran, P., Wines, T.H., Mehta, S.C., Garti, N., Farinato, R., “Emulsions and Their Behavior,” in Surfactants in Personal Care Products and Decorative Cosmetics, Rhein, L.D., O'Lenick, A., Schlossman, M., Somasundaran, P., Eds. (Taylor & Francis, New York, 2006, ed. 3) vol. 135, pp. 149–176.Google Scholar
15.Liu, F., Somasundaran, P., Gryte, C.C., presented at Polyacrylamide Microgel Synthesis, Modification, and Characterization, 222nd ACS Natl. Meet. (Chicago, August 26–30, 2001).Google Scholar
16.Somasundaran, P., Chakraborty, S., Deo, N., Somasundaran, T., Cosmet. Toiletries 121 (12), 47 (2006).Google Scholar
17.Deo, P., Somasundaran, P., Langmuir 21 (9), 3950 (2005).CrossRefGoogle Scholar
18.Somasundaran, P., Chakraborty, S., Deo, P., Deo, N., Somasundaran, T., “Contribution of Surfactants to Personal Care Products,” in Surfactants in Personal Care Products and Decorative Cosmetics, Rhein, L.D., O'Lenick, A., Schlossman, M., Somasundaran, P., Eds. (Taylor & Francis, New York, 2006, ed. 3) vol. 135, pp. 121–135.CrossRefGoogle Scholar
19.Somasundaran, P., Chakraborty, S., Deo, P., Deo, N., Somasundaran, T., Skin Delivery Systems, 247 (2006).Google Scholar
20.Blume, G., Teichmueller, E.E., SOFW J. 125 (1), 12 (1999).Google Scholar
21.Naito, N., Isshiki, T., Riposomu Oyo no Shintenkai, 644 (2005).Google Scholar
22.Jones, M.N., Lyle, I.G., Kaszuba, M., “Cosmetic Conjugates of Liposomes with Lectins,” Eur. Patent EP 0566368 (October 20, 1993).Google Scholar
23.Deo, N., Somasundaran, P., Colloids Surf. A, Physicochem. Eng. Asp. 186 (1–2), 33 (2001).CrossRefGoogle Scholar
24.Deo, N., Somasundaran, P., Colloids Surf. B, Biointerfaces 25 (3), 225 (2002).CrossRefGoogle Scholar
25.Lee, K.P., Trochimowicz, H.J., Reinhardt, C.F., Toxicol. Appl. Pharmacol. 79, 179 (1985).CrossRefGoogle Scholar
26.Mayon, A., Miquel, C., Lejeune, O., Payre, B., Moretto, P., Skin Pharmacol. Physiol. 20 (1), 10 (2007).Google Scholar
27.Nohynek, G.J., Lademann, J., Ribaud, C., Roberts, M.S., Crit. Rev. Toxicol. 37 (3), 251 (2007).Google Scholar
28.Heinrich, U., Fuhst, R., Rittinghausen, S., Creutzenberg, O., Bellmann, B., Koch, W., Levsen, K., Inhal. Toxicol. 7, 533 (1995).CrossRefGoogle Scholar
29.Nel, A., Xia, T., Mädler, L., Li, N., Science 311 (5761), 622 (2006).CrossRefGoogle Scholar
30.Roco, M., Curr. Opin. Biotechnol. 4 (3), 337 (2003).Google Scholar
31.Powell, M.C., Kanarek, M.S., WMJ 105 (2), 16 (2006).Google Scholar
32.Pison, U., Welte, T., Giersig, M., Groneberg, D.A., Eur. J. Pharmacol. 533 (1–3), 341 (2006).CrossRefGoogle Scholar
33.Voura, E.B., Jaiswal, J.K., Mattoussi, H., Simon, S.M., Natl. Med. 10 (9), 993 (2004).Google Scholar
34.Zorov, D.B., Kobrinsky, E., Juhaszova, M., Sollott, S.J., Circ. Res. 95, 239 (2004).Google Scholar
35.Ross, P.E., Technol. Rev. 109 (2), 66 (2006).Google Scholar
36.Warheit, D.B., Laurence, B.R., Reed, K.L., Roach, D.H., Reynolds, G.A.M., Webb, T.R., Toxicol. Sci. 77, 117 (2004).Google Scholar
37.Oberdörster, G., Sharp, Z., Atudorei, V., Elder, A., Gelein, R., Kreyling, W., Cox, C., Inhal. Toxicol. 16 (6–7), 437 (2004).Google Scholar
38.Oberdörster, E., Environ. Health Perspect. 113 (7), 823 (2005).Google Scholar
39.Yang, L., Watts, D., Toxicol. Lett. 158, 122 (2005).CrossRefGoogle Scholar
40.Fortner, J.D., Lyon, D.Y., Sayes, C.M., Boyd, A.M., Falkner, J.C., Hotze, E.M., Alemany, L.B., Tao, Y.J., Guo, W., Ausman, K.D., Colvin, V.L., Hughes, J.B., Environ. Sci. Technol. 39 (11), 4307 (2005).Google Scholar
41.Sayes, C.M., Gobin, A.M., Ausman, K.D., Mendez, J., West, J.L., Colvin, V.L., Biomaterials 26 (36), 7587 (2005).Google Scholar
42.Sayes, C.M., Liang, F., Hudson, J.L., Mendez, J., Guo, W., Beach, J.M., Moore, V.C., Doyle, C.D., West, J.L., Billups, W.E., Ausman, K.D., Colvin, V.L., Toxicol. Lett. 161, 135 (2006).Google Scholar
43.Warheit, D.B., Webb, T.R., Colvin, V.L., Sayes, C.M., Toxicol. Sci. 95 (1), 270 (2007).Google Scholar
44.Sayes, C.M., Reed, K.L., Warheit, D.B., Toxicol. Sci. 97 (1), 163 (2007).Google Scholar
45.Powers, K.W., Brown, S.C., Krishna, V.B., Wasdo, S.C., Moudgil, B.M., Roberts, S.M., S.M., , Toxicol. Sci. 90 (2), 296 (2006).Google Scholar
46.Tsuji, J.S., Maynard, A.D., Howard, P.C., James, J.T., Lam, C., Warheit, D.B., Santamaria, A.B., Toxicol. Sci. 89 (1), 42 (2006).Google Scholar
47.Borm, P., Klaessig, F.C., Landry, T.D., Moudgil, B., Pauluhn, J., Thomas, K., Trottier, R., Wood, S., Toxicol. Sci. 90 (1), 23 (2006).CrossRefGoogle Scholar
48.Jain, K.K., Drug Discov. Today 10 (21), 1435 (2005).CrossRefGoogle Scholar
49.Thomas, K., Sayre, P., Toxicol. Sci. 87 (2), 316 (2005).Google Scholar
50.Thomas, K., Aguar, P., Kawasaki, H., Morris, J., Nakanishi, J., Savage, N., Toxicol. Sci. 92 (1), 23 (2006).Google Scholar
51.Balshaw, D.M., Philbert, M. Martin, Suk, W.A., Toxicol. Sci. 88 (2), 298 (2005).Google Scholar
52.Powell, M.C., Kanarek, M.S., WMJ 105 (3), 18 (2006).Google Scholar
53.Moore, M.N., Environ. Int. 32 (8), 967 (2006).CrossRefGoogle Scholar
54.Powell, M.C., Kanarek, M.S., WMJ 105 (2), 16 (2006).Google Scholar
55.Moser, K., Kriwet, K., Naik, A., Kalia, Y.N., Guy, R.H., Eur. J. Pharm. Biopharm. 52, 103 (2001).CrossRefGoogle Scholar
56.Elias, P.M., Int. J. Dermatol. 20, 1 (1981).Google Scholar