Hostname: page-component-586b7cd67f-t7czq Total loading time: 0 Render date: 2024-11-24T04:02:55.976Z Has data issue: false hasContentIssue false

Fabrication of Three-Dimensional Microfluidic Systems by Soft Lithography

Published online by Cambridge University Press:  31 January 2011

Get access

Extract

Two-dimensional (2D) methods for transferring patterns to planar substrates have enabled the technological revolution in microfabrication that has marked the last 40 years. The overall trend toward increased miniaturization has led to the development of new types of devices in areas unrelated to conventional microelectronics: analytical tools, chemical reactors, microelectromechanical systems (MEMS), optical systems, and sensors. The widespread use and high level of technological development associated with photolithography has also made the methodologies for microelectronics—patterning photosensitive polymers, etching and deposition of thin films, and liftoff—ubiquitous in the fabrication of these new classes of microsystems. These new systems have specialized requirements, however, and are not simple extensions of microelectronics technologies. They often require materials—especially organic polymers—that are not commonly used in microelectronic systems, they must have low cost, and they may need 3D structures in order to implement complex designs. These requirements have stimulated the development of new methods for microfabrication.

Type
Research Article
Copyright
Copyright © Materials Research Society 2001

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Madou, M., Fundamentals of Microfabrication (CRC Press, Boca Raton, FL, 1997); G.T.A. Kovacs, Micromachined Transducers Sourcebook (McGraw- Hill, New York, 1998).Google Scholar
2.Maluf, N., An Introduction to Microelectromechanical Systems Engineering (Artech House, Norwood, MA, 2000); C.S. Effenhauser, A. Manz, and H.M. Widmer, Anal. Chem. 65 (1993) p. 2637; D.J. Harrison, K. Fluri, K. Seiler, Z. Fan, C.S. Effenhauser, and A. Manz, Science 261 (1993) p. 895; R. Kapur, K.A. Hiuliano, M. Camoana, T. Adams, K. Olson, D. Jung, M. Mrksich, C. Vasudevan, and D.L. Taylor, Biomed. Microdevices 2 (1999) p. 99; J.M. Ramsey, S.C. Jacobsen, and M.R. Knapp, Nature Med. 1 (1995) p. 1093; K. Seiler, D.J. Harrison, and A. Manz, Anal. Chem. 65 (1993) p. 1481.Google Scholar
3.Xia, Y., Rogers, J.A., Paul, K.E., and Whitesides, G.M., Chem. Rev. 99 (7) (1999) p. 1823.CrossRefGoogle Scholar
4.Xia, Y. and Whitesides, G.M., Angew. Chem., Int. Ed. Engl. 37 (5) (1998) p. 550.3.0.CO;2-G>CrossRefGoogle Scholar
5.Quake, S. and Scherer, A., Science 290 (2000) p. 1536.CrossRefGoogle Scholar
6.Wu, H., Brittain, S.T., Anderson, J.R., Grzybowski, B., Whitesides, S., and Whitesides, G.M., J. Am. Chem. Soc. 122 (2000) p. 12691.CrossRefGoogle Scholar
7.Jackman, R.J., Brittain, S.T., Adams, A., Prentiss, M.G., and Whitesides, G.M., Science 280 (1998) p. 2089; R.J. Jackman, S.T. Brittain, and G.M. Whitesides, JMEMS 7 (2) (1998) p. 261; E.E. Hui, R.T. Howe, and M.S. Rodgers, in Proc. 13th IEEE Int. Conf. on Micro Electro Mechanical Systems (Institute of Electrical and Electronics Engineers, Piscataway, NJ, 2000).CrossRefGoogle Scholar
8.Black, A.J., Paul, K.E., Aizenberg, J., and Whitesides, G.M., J. Am. Chem. Soc. 121 (36) (1999) p. 8356; J. Aizenberg, A.J. Black, and G.M. Whitesides, Nature 394 (1998) p. 868.CrossRefGoogle Scholar
9.Rogers, J.A., Paul, K.E., Jackman, R.J., and Whitesides, G.M., J. Vac. Sci. Technol., B 26 (1) (1998) p. 59.CrossRefGoogle Scholar
10.Paul, K.E., Breen, T.L., Aizenberg, J., and Whitesides, G.M., Appl. Phys. Lett. 73 (1998) p. 2893.CrossRefGoogle Scholar
11.Love, J.C., Paul, K.E., and Whitesides, G.M., Adv. Mater. 13 (8) (2001) p. 604.3.0.CO;2-J>CrossRefGoogle Scholar
12.Love, J.C., Wolfe, D.B., Jacobs, H.O., and Whitesides, G.M., Langmuir (2001) submitted for publication.Google Scholar
13.McDonald, J.C., Duffy, D.C., Anderson, J.R., Chiu, D.T., Wu, H.K., Schueller, O.J.A., and Whitesides, G.M., Electrophoresis 21 (1) (2000) p. 27.3.0.CO;2-C>CrossRefGoogle Scholar
14.Duffy, D.C., McDonald, J.C., Schueller, O.J.A., and Whitesides, G.M., Anal. Chem. 70 (23) (1998) p. 4974.CrossRefGoogle Scholar
15.Morra, M., Occhiello, E., Marola, R., Garbassi, F., Humphrey, P., and Johnson, D., J. Colloid Interface Sci. 137 (1990) p. 11.CrossRefGoogle Scholar
16.Batchelor, G.K., An Introduction to Fluid Dynamics (Cambridge University Press, Cambridge, UK, 1967).Google Scholar
17.Anderson, J.R., Chiu, D.T., Jackman, R.J., Cherniavskaya, O., McDonald, J.C., Wu, H.K., Whitesides, S.H., and Whitesides, G.M., Anal. Chem. 72 (14) (2000) p. 3158.CrossRefGoogle Scholar
18.Takayama, S., McDonald, J.C., Ostuni, E., Liang, M.N., Kenis, P.J.A., Ismagilov, R.F., and Whitesides, G.M., Proc. Natl. Acad. Sci. 96 (10) (1999) p. 5545; P.J.A. Kenis, R.F. Ismagilov, and G.M. Whitesides, Science 285 (5424) (1999) p. 83.CrossRefGoogle Scholar
19.Takayama, S., Ostuni, E., Qian, X., McDonald, J.C., Jiang, X., LeDuc, P., Wu, M.H., Ingber, D.E., and Whitesides, G.M., Adv. Mater. 13 (8) (2001) p. 570.3.0.CO;2-B>CrossRefGoogle Scholar
20.Weigl, B.H. and Yager, P., Science 283 (1999) p. 346.CrossRefGoogle Scholar
21.Jeon, N.L., Dertinger, S.K.W., Chiu, D.T., Choi, I.S., Stroock, A.D., and Whitesides, G.M., Langmuir 16 (22) (2000) p. 8311.CrossRefGoogle Scholar
22.Liu, R.H., Stremler, M.A., Sharp, K.V., Olsen, M.G., Santiago, J.G., Adrian, R.J., Aref, H., and Beebe, D.J., JMEMS 9 (2) (2000).Google Scholar
23.Ismagilov, R.F., Rosmarin, D., Kenis, P.J.A., Chiu, D.T., Zhang, W., Stone, H.A., and Whitesides, G.M., Anal. Chem. (2001) submitted for publication.Google Scholar
24.Chiu, D.T., Pezzoli, E., Wu, H., Stroock, A.D., and Whitesides, G.M., Proc. Natl. Acad. Sci. 98 (6) (2001) p. 2961.CrossRefGoogle Scholar
25.Beebe, D.J., Moore, J.S., Bauer, J.M., Yu, Q., Liu, R.H., Devadoss, C., and Jo, B.-H., Nature 404 (2000) p. 588; D.C. Duffy, O.J.A. Schueller, S.T. Brittain, and G.M. Whitesides, J. Micromechan. Microeng. 9 (3) (1999) p. 211; M.A. Unger, H.-P. Chou, T. Thorsen, A. Scherer, and S.R. Quake, Science 288 (2000) p. 113.CrossRefGoogle Scholar
26.Jeon, N.L., Chiu, D.T., Wargo, C.J., Wu, H., Choi, I.S., Anderson, J.R., and Whitesides, G.M. (unpublished manuscript).Google Scholar
27.Jackman, R.J., Duffy, D.C., Cherniavskaya, O., and Whitesides, G.M., Langmuir 15 (8) (1999) p. 2973.CrossRefGoogle Scholar
28.Chiu, D.T., Jeon, N.L., Huang, S., Kane, R.S., Wargo, C.J., Choi, I.S., Ingber, D.E., and Whitesides, G.M., Proc. Natl. Acad. Sci. 97 (6) (2000) p. 2408.CrossRefGoogle Scholar
29.Xu, B., Arias, F., Brittain, S.T., Zhao, X.-M., Grzybowski, B., Torquato, S., and Whitesides, G.M., Adv. Mater. 11 (14) (1999) p. 1186.3.0.CO;2-K>CrossRefGoogle Scholar
30.Rogers, J.A., Jackman, R.J., and Whitesides, G.M., Adv. Mater. 9 (6) (1997) p. 475.CrossRefGoogle Scholar
31.Wu, H. (unpublished manuscript).Google Scholar
32.Rogers, J.A., Paul, K.E., Jackman, R.J., and Whitesides, G.M., Appl. Phys. Lett. 70 (20) (1997) p. 2658.CrossRefGoogle Scholar
33.Han, J. and Craighead, H.G., Science 288 (2000) p. 1026.CrossRefGoogle Scholar