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The evolution of nitrocellulose as a material for bioassays

Published online by Cambridge University Press:  12 April 2013

Gina E. Fridley ,
Carly A. Holstein ,
Shefali B. Oza  and
Paul Yager
Gina E. Fridley
Affiliation:
Bioengineering Department, University of Washington; [email protected]
Carly A. Holstein
Affiliation:
Bioengineering Department, University of Washington; [email protected]
Shefali B. Oza
Affiliation:
Bioengineering Department, University of Washington; [email protected]
Paul Yager
Affiliation:
Bioengineering Department, University of Washington; [email protected]
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Abstract

The need to improve health outcomes in the developing world and to moderate healthcare costs in developed countries has resulted in an increased interest in sophisticated, inexpensive, and instrument-free point-of-care diagnostics using porous materials. One major segment of the paper-based diagnostics effort is focused on developing high-performance point-of-care tests using porous nitrocellulose membranes. This review provides a perspective on the nature, history, and future of nitrocellulose-based assays. Beginning as a protein blotting substrate, porous nitrocellulose membranes have grown to be the most commonly used lateral flow substrate and are the primary membranes used in two-dimensional paper networks for user-friendly multistep assays. In addition to the historical context, we examine assay development considerations, such as the physics of flow in porous media, reagent deposition and storage, and detection methods.

Keywords

porositybiomedicaldevicesfluidicssensor
Type
Research Article
Information
MRS Bulletin , Volume 38 , Issue 4: Paper-based technology , April 2013 , pp. 326 - 330
Copyright
Copyright © Materials Research Society 2013

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Footnotes

*

These authors all contributed equally to this article.

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