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Enzyme-functionalized DNA nanostructures as tools for organizing and controlling enzymatic reactions

Published online by Cambridge University Press:  08 December 2017

Guido Grossi ,
Andreas Jaekel ,
Ebbe Sloth Andersen  and
Barbara Saccà
Guido Grossi
Affiliation:
Interdisciplinary Nanoscience Center, Aarhus University, Denmark; [email protected]
Andreas Jaekel
Affiliation:
Center of Medical Biotechnology, Bionanotechnology Group, University of Duisburg-Essen, Germany; [email protected]
Ebbe Sloth Andersen
Affiliation:
Interdisciplinary Nanoscience Center, Aarhus University, Denmark; [email protected]
Barbara Saccà
Affiliation:
Center of Medical Biotechnology, Bionanotechnology Group, University of Duisburg-Essen, Germany; [email protected]
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Abstract

Enzyme sequestration and compartmentalization are key factors in cell signaling and metabolism, evolved to solve the challenges of slow turnover rates, undesired pathway intermediates, and competing reactions. Inspired by nature, DNA nanoengineers have developed organizational systems to confine enzymes in two- and three-dimensional environments and to actuate them in response to precise external stimuli. DNA-scaffolded enzymes have applications for not only the in vitro reconstitution of proteins, peptides, and other molecular assemblies, but also to enable the generation of advanced functional nanomaterials for the development of, for example, fuel cells, biosensors, and drug delivery systems. Despite several challenges that still remain unsolved, the use of DNA scaffolds to arrange enzymes in space and time will help to realize biochemical nanofactories, where multiple components work together to produce novel and improved functional materials, rivaling the efficiency of biological systems.

Type
Research Article
Information
MRS Bulletin , Volume 42 , Issue 12: DNA Nanotechnology: A foundation for Programmable Nanoscale Materials , December 2017 , pp. 920 - 924
Copyright
Copyright © Materials Research Society 2017 

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