Hostname: page-component-586b7cd67f-vdxz6 Total loading time: 0 Render date: 2024-11-28T01:15:38.409Z Has data issue: false hasContentIssue false

Clinical translational challenges in nanomedicine

Published online by Cambridge University Press:  13 March 2014

Shiladitya Sengupta*
Affiliation:
Brigham and Women’s Hospital and Harvard Medical School; [email protected]
Get access

Abstract

After a decade of active research, pressure is mounting for clinical translation of nanomedicines. However, to enable success in the clinic, it is important to understand the factors that can pose challenges. For example, reduction in adverse effects alone might not be enough of a driver today for clinical translation. The benchmark for clinical translation will be increased efficacy, a significant challenge to overcome if nanomedicines are developed only from a drug delivery perspective. Success in clinics will therefore require a re-examination of the design of nanomedicines, including challenging current dogmas. What can we learn from translational experience with recently approved antibody-drug conjugates, which like nanomedicines is another approach to deliver chemotherapy agents selectively to the tumors? Nanomedicines can address some of the emerging challenges in cancer chemotherapy, including heterogeneity and adaptive resistance, which can offer unique translational opportunities. This article addresses some of these themes and strategies that can facilitate translation of nanomedicines to the clinic.

Type
Research Article
Copyright
Copyright © Materials Research Society 2014 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Ferrari, M., Nat. Rev. Cancer 5, 161 (2005).CrossRefGoogle Scholar
Wang, A.Z., Langer, R., Farokhzad, O.C., Annu. Rev. Med. 63, 185 (2012).CrossRefGoogle Scholar
Moghimi, S.M., Hunter, A.C., Murray, J.C.. Pharmacol. Rev. 53, 283 (2001).Google Scholar
Marjan, J.M., Allen, T.M., Biotechnol. Adv. 14, 151 (1996).CrossRefGoogle Scholar
Allen, T.M., Cullis, P.R., Adv. Drug Deliv. Rev. 65, 36 (2013).CrossRefGoogle Scholar
Yuan, F., Dellian, M., Fukumura, D., Leunig, M., Berk, D.A., Torchilin, V.P., Jain, R.K., Cancer Res. 55, 3752 (1995).Google Scholar
Yuan, F., Leunig, M., Huang, S.K., Berk, D.A., Papahadjopoulos, D., Jain, R.K., Cancer Res. 54, 3352 (1994).Google Scholar
Northfelt, D.W., Martin, F.J., Working, P., Volberding, P.A., Russell, J., Newman, M, Amantea, M.A., Kaplan, L.D., J. Clin. Pharmacol. 36, 55 (1996).CrossRefGoogle Scholar
Barenholz, Y., J. Control. Release 160, 117 (2012).CrossRefGoogle Scholar
Batist, G., Barton, J., Chaikin, P., Swenson, C., Welles, L., Expert Opin. Pharmacother. 3, 1739 (2002).CrossRefGoogle Scholar
Desai, N., Trieu, V., Yao, Z., Louie, L., Ci, S., Yang, A., Tao, C., De, T., Beals, B., Dykes, D., Noker, P., Yao, R., Labao, E., Hawkins, M., Soon-Shiong, P., Clin. Cancer Res. 12, 1317 (2006).CrossRefGoogle Scholar
Malam, Y., Loizidou, M., Seifalian, A.M., Trends Pharmacol. Sci. 30, 592 (2009).CrossRefGoogle Scholar
Ma, P., Mumper, R.J., J. Nanomed. Nanotechnol. 4, 1000164 (2013).CrossRefGoogle Scholar
Alexis, F., Pridgen, E., Molnar, L.K., Farokhzad, O.C., Mol. Pharm. 5, 505 (2008).CrossRefGoogle Scholar
Song, G., Wu, H., Yoshino, K., Zamboni, W.C., J. Liposome Res. 22, 177 (2012).CrossRefGoogle Scholar
Gref, R., Lück, M., Quellec, P., Marchand, M., Dellacherie, E., Harnisch, S., Blunk, T., Müller, R.H., Colloids Surf. B, Biointerfaces 18, 301 (2000).CrossRefGoogle Scholar
Stefanick, J.F., Ashley, J.D., Kiziltepe, T., Bilgicer, B., ACS Nano 7, 2935 (2013).CrossRefGoogle Scholar
Li, S.D., Huang, L., J. Control. Release 145, 178 (2010).CrossRefGoogle Scholar
Albanese, A., Tang, P.S., Chan, W.C., Annu. Rev. Biomed. Eng. 14, 1 (2012).CrossRefGoogle Scholar
Loverde, S.M., Klein, M.L., Discher, D.E., Adv. Mater. 24, 3823 (2012).CrossRefGoogle Scholar
Chithrani, B.D., Chan, W.C., Nano Lett. 7, 1542 (2007).CrossRefGoogle Scholar
Choi, H.S., Liu, W., Misra, P., Tanaka, E., Zimmer, J.P., Itty Ipe, B., Bawendi, M.G., Frangioni, J.V., Nat. Biotechnol. 25, 1165 (2007).CrossRefGoogle Scholar
Jain, R.K., Stylianopoulos, T., Nat. Rev. Clin. Oncol. 7, 653 (2010).CrossRefGoogle Scholar
Chauhan, V.P., Stylianopoulos, T., Martin, J.D., Popović, Z., Chen, O., Kamoun, W.S., Bawendi, M.G., Fukumura, D., Jain, R.K., Nat. Nanotechnol. 7, 383 (2012).CrossRefGoogle Scholar
O’Brien, M.E., Wigler, N., Inbar, M., Rosso, R., Grischke, E., Santoro, A., Catane, R., Kieback, D.G., Tomczak, P., Ackland, S.P., Orlandi, F., Mellars, L., Alland, L., Tendler, C., CAELYX Breast Cancer Study Group, Ann. Oncol. 15, 440 (2004).CrossRefGoogle Scholar
Chan, S., Davidson, N., Juozaityte, E., Erdkamp, F., Pluzanska, A., Azarnia, N., Lee, L.W., Ann. Oncol. 15, 1527 (2004).CrossRefGoogle Scholar
Chaudhuri, P., Harfouche, R., Soni, S., Hentschel, D.M., Sengupta, S., ACS Nano 4, 574 (2010).CrossRefGoogle Scholar
Chaudhuri, P., Paraskar, A., Soni, S., Mashelkar, R.A., Sengupta, S., ACS Nano 3, 2505 (2009).CrossRefGoogle Scholar
Chaudhuri, P., Soni, S., Sengupta, S., Nanotechnology 21, 025102 (2010).CrossRefGoogle Scholar
Kelland, L., Nat. Rev. Cancer 7, 573 (2007).CrossRefGoogle Scholar
Madias, N.E., Harrington, J.T., Am. J. Med. 65, 307 (1978).CrossRefGoogle Scholar
Al-Khatib, T., Cohen, N., Carret, A.S., Daniel, S., Int. J. Pediatr. Otorhinolaryngol. 74, 913 (2010).CrossRefGoogle Scholar
White, S.C., Lorigan, P., Margison, G.P., Margison, J.M., Martin, F., Thatcher, N., Anderson, H., Ranson, M., Br. J. Cancer 95, 822 (2006).CrossRefGoogle Scholar
Zamboni, W.C., Gervais, A.C., Egorin, M.J., Schellens, J.H., Zuhowski, E.G., Pluim, D., Joseph, E., Hamburger, D.R., Working, P.K., Colbern, G., Tonda, M.E., Potter, D.M., Eiseman, J.L., Cancer Chemother. Pharmacol. 53, 329 (2004).CrossRefGoogle Scholar
Avgoustakis, K., Beletsi, A., Panagi, Z., Klepetsanis, P., Karydas, A.G., Ithakissios, D.S., J. Control. Release 79, 123 (2002).CrossRefGoogle Scholar
Fujiyama, J., Nakase, Y., Osaki, K., Sakakura, C., Yamagishi, H., Hagiwara, A., J. Control. Release 89, 397 (2003).CrossRefGoogle Scholar
Dhar, S., Gu, F.X., Langer, R., Farokhzad, O.C., Lippard, S.J., Proc. Natl. Acad. Sci. U.S.A. 105, 17356 (2008).CrossRefGoogle Scholar
Haxton, K.J., Burt, M.H., J. Pharm. Sci. 98, 2299 (2009).CrossRefGoogle Scholar
Rademaker-Lakhai, J.M., Terret, C., Howell, S.B., Baud, C.M., de Boer, R.F., Pluim, D., Beijnen, J.H., Schellens, J.H.M., Droz, J.-P., Clin. Cancer Res. 10, 3386 (2004).CrossRefGoogle Scholar
Lin, X., Zhang, Q., Rice, J.R., Stewart, D.R., Nowotnik, D.P., Howell, S.B., Eur. J. Cancer 40, 291 (2004).CrossRefGoogle Scholar
Sengupta, P., Basu, S., Soni, S., Pandey, A., Roy, B., Oh, M.S., Chin, K.T., Paraskar, A.S., Sarangi, S., Connor, Y., Sabbisetti, V.S., Kopparam, J., Kulkarni, A., Muto, K., Amarasiriwardena, C., Jayawardene, I., Lupoli, N., Dinulescu, D.M., Bonventre, J.V., Mashelkar, R.A., Sengupta, S., Proc. Natl. Acad. Sci. U.S.A. 109, 11294 (2012).CrossRefGoogle Scholar
Paraskar, A.S., Soni, S., Chin, K.T., Chaudhuri, P., Muto, K.W., Berkowitz, J., Handlogten, M.W., Alves, N.J., Bilgicer, B., Dinulescu, D.M., Mashelkar, R.A., Sengupta, S., Proc. Natl. Acad. Sci. U.S.A. 107, 12435 (2010).CrossRefGoogle Scholar
Ng, S.S., Sparreboom, A., Shaked, Y., Lee, C., Man, S., Desai, N., Soon-Shiong, P., Figg, W.D., Kerbel, R.S., Clin. Cancer Res. 12, 4331 (2006).CrossRefGoogle Scholar
Bedard, P.L., Di Leo, A., Piccart-Gebhart, M.J., Nat. Rev. Clin. Oncol. 7, 22 (2010).CrossRefGoogle Scholar
Zhang, Z., Mei, L., Feng, S.S., Expert Opin. Drug Deliv. 10, 325 (2013).CrossRefGoogle Scholar
Hennenfent, K.L., Govindan, R., Ann. Oncol. 17, 735 (2006).CrossRefGoogle Scholar
Koudelka, S., Turanek, J., J. Control. Release 163, 322 (2012).CrossRefGoogle Scholar
Teicher, B.A., Chari, R.V., Clin. Cancer Res. 17, 6389 (2011).CrossRefGoogle Scholar
Beck, A., Haeuw, J.F., Wurch, T., Goetsch, L., Bailly, C., Corvaïa, N., Discov. Med. 10, 329 (2010).Google Scholar
Cheng, J., Khin, K.T., Davis, M.E., Mol. Pharm. 1, 183 (2004).CrossRefGoogle Scholar
Perry, J.L., Reuter, K.G., Kai, M.P., Herlihy, K.P., Jones, S.W., Luft, J.C., Napier, M., Bear, J.E., DeSimone, J.M., Nano Lett. 12, 5304 (2012).CrossRefGoogle Scholar
Kreso, A., O’Brien, C.A., van Galen, P., Gan, O.I., Notta, F., Brown, A.M.K., Ng, K., Ma, J., Wienholds, E., Dunant, C., Pollett, A., Gallinger, S., McPherson, J., Mullighan, C.G., Shibata, D., Dick, J.E., Science 339, 543 (2013).CrossRefGoogle Scholar
Shackleton, M., Quintana, E., Fearon, E.R., Morrison, S.J., Cell 138, 822 (2009).CrossRefGoogle Scholar
Almendro, V., Marusyk, A., Polyak, K., Annu. Rev. Pathol. 8, 277 (2013).CrossRefGoogle Scholar
Brock, A., Chang, H., Huang, S., Nat. Rev. Genet. 10, 336 (2009).CrossRefGoogle Scholar
Marusyk, A., Polyak, K., Science 339, 528 (2013).CrossRefGoogle Scholar
Pandey, A., Kulkarni, A., Roy, B., Goldman, A., Sarangi, S., Sengupta, P., Phipps, C., Kopparam, J., Oh, M., Basu, S., Kohandel, M., Sengupta, S., Cancer Res. (October 11, 2013); http://www.ncbi.nlm.nih.gov/pubmed/24121494.Google Scholar
Kulkarni, A.A., Roy, B., Rao, P.S., Wyant, G.A., Mahmoud, A., Ramachandran, M., Sengupta, P., Goldman, A., Kotamraju, V.R., Basu, S., Mashelkar, R.A., Ruoslahti, E., Dinulescu, D.M., Sengupta, S., Cancer Res. 73 (23), 6987 (2013).CrossRefGoogle Scholar
Lee, M.J., Ye, A.S., Gardino, A.K., Heijink, A.M., Sorger, P.K., MacBeath, G., Yaffe, M.B., Cell 149, 780 (2012).CrossRefGoogle ScholarPubMed
Sengupta, S., Eavarone, D., Capila, I., Zhao, G., Watson, N., Kiziltepe, T., Sasisekharan, R., Nature 436, 568 (2005).CrossRefGoogle Scholar