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Bio-Resorbable Nanoceramics for Gene and Drug Delivery

Published online by Cambridge University Press:  31 January 2011

Waltraud M. Kriven ,
Seo-Young Kwak ,
Matthew A. Wallig  and
Jin-Ho Choy
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Abstract

Nanoscale ceramic particles, such as layered double hydroxides (LDHs), have been developed to deliver drugs or genes into biological cells. In this article, we describe the controlled-release properties of LDHs as drug delivery carriers, the formation of bio-LDH nanohybrids, their in vivo and in vitro cytotoxicity tests, and their potential as anticancer gene delivery carriers. Unstable biomolecules can be intercalated into LDHs, displacing the interlayer anions; the drug or gene's negative charge is thus shielded, enabling penetration into the cell. In the slightly acidic environment of the cell, ceramic nanoplatelets of ∼100 nm diameter dissolve, thus releasing the intercalates in a controlled manner.

Keywords

biomedical materialsceramicsdrug deliveryintercalationnonviral vectorssafety studiesscanning electron microscopy (SEM)transmission electron microscopy (TEM)
Type
Research Article
Information
MRS Bulletin , Volume 29 , Issue 1: Toward Applications of Ceramic Nanostructures , January 2004 , pp. 33 - 37
Copyright
Copyright © Materials Research Society 2004

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