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Molecular imaging with surface-enhanced Raman spectroscopy nanoparticle reporters

Published online by Cambridge University Press:  09 August 2013

Jesse V. Jokerst ,
Christoph Pohling  and
Sanjiv S. Gambhir
Jesse V. Jokerst
Affiliation:
Molecular Imaging Program, Stanford University;[email protected]
Christoph Pohling
Affiliation:
Molecular Imaging Program, Stanford University;[email protected]
Sanjiv S. Gambhir
Affiliation:
Molecular Imaging Program, Stanford University;[email protected]
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Abstract

Molecular imaging scans cellular and molecular targets in living subjects through the introduction of imaging agents that bind to these targets and report their presence through a measurable signal. The picomolar sensitivity, signal stability, and high multiplexing capacity of Raman spectroscopy satisfies important needs within the field of molecular imaging, and several groups now utilize Raman and surface-enhanced Raman spectroscopy to image molecular targets in small animal models of human disease. This article details the role of Raman spectroscopy in molecular imaging, describes some substrates and imaging agents used in animal models, and illustrates some examples.

Keywords

Contrast agentmolecular imagingnanoparticleRaman spectroscopySERS
Type
Research Article
Information
MRS Bulletin , Volume 38 , Issue 8: Surface-enhanced Raman spectroscopy: Substrates and materials , August 2013 , pp. 625 - 630
Copyright
Copyright © Materials Research Society 2013 

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