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Molecular Design of β-Hairpin Peptides for Material Construction

Published online by Cambridge University Press:  31 January 2011

Ronak V. Rughani  and
Joel P. Schneider
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Abstract

Self-assembled materials composed of β-sheet forming peptides hold promise as therapeutics and novel biomaterials. This article focuses on the design and engineering of amphiphilic peptide sequences, especially β-hairpins. Peptides can be designed to intramolecularly fold and then self-assemble on cue, affording hydrogels rich in β-sheet structure. Hydrogels having distinct material properties can be designed at the molecular level by modulating either the peptide's sequence or the environmental stimulus used to trigger folding and assembly, leading to gelation.

Type
Research Article
Information
MRS Bulletin , Volume 33 , Issue 5: Molecular Biomimetics , May 2008 , pp. 530 - 535
Copyright
Copyright © Materials Research Society 2008

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