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Genetically encoded “smart” peptide polymers for biomedicine

Published online by Cambridge University Press:  10 January 2014

Eric Mastria  and
Ashutosh Chilkoti
Eric Mastria
Affiliation:
Duke University, Durham, NC; [email protected]
Ashutosh Chilkoti
Affiliation:
Department of Biomedical Engineering, Duke University, Durham, NC; [email protected]
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Abstract

Drug delivery systems are becoming increasingly sophisticated, with the ability to target and penetrate specific tissues and release drugs based upon the local environment. While these advanced systems often offer advantages over their less sophisticated counterparts, the final product may be more complex and require additional manufacturing steps. In this article, we review a body of work based on genetically encoded elastin-like polypeptides (ELPs) that offer a route to modular, multifunctional delivery systems that are simple to manufacture. ELPs are temperature-sensitive biopolymers that can be designed on the genetic level and expressed in cell-based protein production systems. The tools of molecular biology and versatility of proteins are used to engineer polymers with precise composition and molecular weight that self-assemble to form drug delivery systems with an impressive variety of features and functions. Due to their versatility and ease of production, ELPs are likely to contribute to the goal of designing simple and effective “smart” delivery systems.

Keywords

biomaterialnanostructureself-assemblybiological synthesis (assembly)chemical composition
Type
Research Article
Information
MRS Bulletin , Volume 39 , Issue 1: Materials for Biological Modulation, Sensing, and Imaging , January 2014 , pp. 35 - 43
Copyright
Copyright © Materials Research Society 2014 

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