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Applications of Biomembranes in Drug Discovery

Published online by Cambridge University Press:  31 January 2011

Ye Fang ,
Yulong Hong ,
Brian Webb  and
Joydeep Lahiri
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Abstract

Molecules in the cell membrane are key targets for therapeutic intervention. Technologies that enable the preservation of membrane-bound targets in their biomimetic and pharmacologically active states for screening of potential drug compounds are of great interest to bio-pharmaceutical companies. This review discusses emerging biomembrane technologies with a focus on biomembrane microarrays that enable the parallel analysis of multiple membrane-bound targets.

Keywords

biologicalbiomedicalbiomimeticcellular
Type
Research Article
Information
MRS Bulletin , Volume 31 , Issue 7: Materials Science of Supported Lipid Membranes , July 2006 , pp. 541 - 545
Copyright
Copyright © Materials Research Society 2006

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References

1Simons, K. and Ikonen, E., Science 290 (2000) p.1721.CrossRefGoogle ScholarPubMed
2Ianoul, A., Grant, D.D., Rouleau, Y., Bani-Yaghoub, M., Johnston, L.J., and Pezacki, J.P., Nat. Chem. Biol. 1 (2005) p.196.CrossRefGoogle Scholar
3Drews, J., Science 287 (2000) p.1960.CrossRefGoogle Scholar
4Ma, P. and Zemmel, R., Nat. Rev. Drug Discov. 1 (2002) p.571.CrossRefGoogle Scholar
5Fang, Y., Lahiri, J., and Picard, L., Drug Discovery Today 8 (2003) p.755.CrossRefGoogle Scholar
6Schlessinger, J., Cell 103 (2000) p.211.CrossRefGoogle ScholarPubMed
7Kholodenko, B.N., Exper, J.. Biol. 206 (2003) p.2073.Google Scholar
8Fang, Y., Li, G., and Peng, J., FEBS Lett. 579 (2005) p.6365.CrossRefGoogle Scholar
9Sato, T.K., Overduin, M., and Emr, S.D., Science 294 (2001) p.1881.CrossRefGoogle Scholar
10Tamm, L.K. and McConnell, H.M., Biophys. J. 47 (1985) p.105.CrossRefGoogle Scholar
11Sackmann, E., Science 271 (1986) p.43.CrossRefGoogle Scholar
12Groves, J.T. and Dustin, M.L., J. Immunol. Meth. 278 (2003) p.19.CrossRefGoogle Scholar
13Groves, J.T., Ulman, N., and Boxer, S.G., Science 275 (1997) p.651.CrossRefGoogle Scholar
14Groves, J.T. and Boxer, S.G., Acc. Chem. Res. 35 (2002) p.149.CrossRefGoogle Scholar
15Brian, A.A. and McConnell, H.M., Proc. Natl. Acad. Sci. USA 81 (1984) p.6159.CrossRefGoogle Scholar
16Kloboucek, A., Behrisch, A., Faix, J., and Sackmann, E., Biophys. J. 77 (1999) p.2311.CrossRefGoogle Scholar
17Shaw, J.E., Slade, A., and Yip, C.M., J. Am. Chem. Soc. 125 (2003) p.11838.CrossRefGoogle Scholar
18Sackmann, E. and Tanaka, M., Trends Biotech-nol. 18 (2000) p.58.CrossRefGoogle Scholar
19Tanaka, M. and Sackmann, E., Nature 437 (2005) p.656.CrossRefGoogle Scholar
20Schena, M., Shalon, D., Davis, R.W., and Brown, P. O., Science 270 (1995) p.467.CrossRefGoogle Scholar
21Ferguson, J.A., Steemers, F.J., and Walt, D.R., Anal. Chem. 72 (2000) p.5618.CrossRefGoogle Scholar
22Fang, Y. and Yang, J., Biochim. Biophys. Acta 1324 (1997) p.309.CrossRefGoogle Scholar
23Fang, Y., Frutos, A.G., and Lahiri, J., Chem-Biochem 3 (2002) p.987.Google Scholar
24Hong, Y., Webb, B.L., Su, H., Mozdy, E., Fang, Y., Wu, C., Liu, L., Beck, J., Ferrie, A., Ragha-van, S., Mauro, J., Carre, A., Müller, D., Lai, F., Ras-now, B., Johnson, M., Min, H., Salon, J., and Lahiri, J., J.Am. Chem. Soc. 127 (2005) p.15350.CrossRefGoogle Scholar
25Fang, Y., Frutos, A.G., and Lahiri, J., J. Am. Chem. Soc. 124 (2002) p.2394.CrossRefGoogle Scholar
26Fang, Y., Frutos, A.G., and Lahiri, J., Langmuir 19 (2003) p.1500.CrossRefGoogle Scholar
27Groves, J.T., Mahal, L.K., and Bertozzi, C.R., Langmuir 17 (2001) p.5129.CrossRefGoogle Scholar
28Yang, T., Baryshnikova, O.K., Mao, H., Holden, M.A., and Cremer, P.S., J. Am. Chem. Soc. 125 (2003) p.4779.CrossRefGoogle Scholar
29Orth, R.N., Wu, M., Holowka, D.A., Craighead, H.G., and Baird, B.A., Langmuir 19 (2003) p.1599.CrossRefGoogle Scholar
30Pautot, S., Lee, H., Isacoff, E.Y., and Groves, J.T., Nat. Chem. Biol. 1 (2005) p.283.CrossRefGoogle Scholar
31Yamazaki, V., Sirenko, O., Schafer, R.J., and Groves, J.T., J. Am. Chem. Soc. 127 (2005) p.2826.CrossRefGoogle Scholar
32Oudenaarden, A. van and Boxer, S.G., Science 285 (1999) p.1046.CrossRefGoogle Scholar
33Moran-Mirabal, J.M., Edel, J.B., Meyer, G.D., Throckmorton, D., Singh, A.K., and Craig-head, H.G., Biophys. J. 89 (2005) p.296.CrossRefGoogle Scholar
34Burridge, K.A., Figa, M.A., and Wong, J.Y., Langmuir 20 (2004) p.10252.CrossRefGoogle Scholar
35Yamazaki, V., Sirenko, O., Schafer, R.J., Nguyen, L., Gutsmann, T., Brade, L., and Groves, J.T., BMC Biotechnol. 5 (2005) p.18.CrossRefGoogle Scholar
36Fang, Y., Peng, J., Ferrie, A.M., and Burkhalter, R.S., Anal. Chem. 78 (2006) p.149.CrossRefGoogle Scholar
37Holden, M.A., Jung, S.-Y., Yang, T., Castellana, E.T., and Cremer, P.S., J. Am. Chem. Soc. 126 (2004) p.6512.CrossRefGoogle Scholar
38Hovis, J.S. and Boxer, S.G., Langmuir 17 (2001) p.3400.CrossRefGoogle Scholar
39Cremer, P.S. and Yang, J.T., J. Am. Chem. Soc. 121 (1999) p.8130.CrossRefGoogle Scholar
40Morigaki, K., Baumgart, T., Offenhausser, A., and Knoll, W., Ang. Chem. Int. Ed. 40 (2001) p.172.3.0.CO;2-G>CrossRefGoogle Scholar
41Orth, R.N., Kameoka, J., Zipfel, W.R., Ilic, B., Webb, W.W., Clark, T.G., and Craighead, H.G., Biophys. J. 85 (2003) p.2066.CrossRefGoogle Scholar
42Hovis, J.S. and Boxer, S.G., Langmuir 16 (2000) p.894.CrossRefGoogle Scholar
43Kung, L.A., Kam, L., Hovis, J.S., and Boxer, S.G., Langmuir 16 (2000) p.6773.CrossRefGoogle Scholar
44Phizicky, E., Bastiaens, P.I.H., Zhu, H., Snyder, M., and Fields, S., Nature 422 (2003) p. 208.CrossRefGoogle Scholar
45Lang, H., Duschl, C., and Vogel, H., Langmuir 10 (1994) p.197.CrossRefGoogle Scholar
46Lahiri, J., Kalal, P., Frutos, A.G., Jonas, S.J., and Schaeffler, R., Langmuir 16 (2000) p.7805.CrossRefGoogle Scholar
47Fang, Y., Cheley, S., Bayley, H., and Yang, J., Biochemistry 36 (1997) p.9518.CrossRefGoogle Scholar
48Fang, Y., Ferrie, A.M., and Lai, F., in The Proteomics Protocols Handbook, edited by Walker, J.M. (Humana Press, Totowa, NJ, 2005) p.723.CrossRefGoogle Scholar
49Haga, T. and Berstein, G., eds. G Protein-Coupled Receptors (CRC Press, Boca Raton, FL, 1999).Google Scholar
50Bardos-Nagy, I., Galantai, R., Laberge, M., and Fidy, J., Langmuir 19 (2003) p.146.CrossRefGoogle Scholar
51Luzardo, M.C., Amalfa, F., Nunez, A.M., Diaz, S., Lopez, A.C.B., and Disalvo, E.A., Biophys. J. 78 (2000) p. 2452.CrossRefGoogle Scholar