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Advanced human in vitro models to assess metal oxide nanoparticle-cell interactions

Published online by Cambridge University Press:  13 November 2014

Peter Wick ,
Stefanie Grafmueller ,
Alke Petri-Fink  and
Barbara Rothen-Rutishauser
Peter Wick
Affiliation:
Empa, Swiss Federal Laboratories for Materials Science and Technology, Switzerland; [email protected]
Stefanie Grafmueller
Affiliation:
Empa, Swiss Federal Laboratories for Materials Science and Technology, Switzerland; [email protected]
Alke Petri-Fink
Affiliation:
Adolphe Merkle Institute, University of Fribourg, Switzerland; [email protected]
Barbara Rothen-Rutishauser
Affiliation:
Adolphe Merkle Institute, University of Fribourg, Switzerland; [email protected]
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Abstract

Engineered nanoparticles, in particular metal oxide nanoparticles, with their unique and novel properties, enable a plethora of new applications in various fields of research. These new properties have raised concerns about potential adverse effects for the environment and human health and are nowadays very controversial. A reliable, cost- and time-effective, rapid and mechanistic-based testing strategy is needed to replace current conventional phenomenological assessments. Today’s in vitro technology, providing human-based advanced cellular models representing different organ barriers such as skin, lung, placenta, or liver, may cover this need. The aim of this article is to present the current changes in (nano) toxicology strategies, the extent to which in vitro models have achieved general acceptance, and how the relevance of these models can further be improved using examples of selected metal oxide nanoparticles.

Keywords

humancellularmetal oxidescolloidsustainabilitybiological barriers
Type
Research Article
Information
MRS Bulletin , Volume 39 , Issue 11: Biological Interactions of Oxide Nanoparticles: The Good and The Evil , November 2014 , pp. 984 - 989
Copyright
Copyright © Materials Research Society 2014 

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