Hostname: page-component-78c5997874-m6dg7 Total loading time: 0 Render date: 2024-11-07T23:21:07.024Z Has data issue: false hasContentIssue false
  • English
  • Français

Two phase microfluidics with inviscid drops: Effects of total flow rate and delayed surfactant addition

Published online by Cambridge University Press:  04 July 2016

Fabian Friess ,
Andreas Lendlein  and
Christian Wischke
Fabian Friess*
Affiliation:
Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Kantstr. 55, 14513 Teltow, Germany Institute of Chemistry, University of Potsdam, 14469 Potsdam, Germany
Andreas Lendlein
Affiliation:
Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Kantstr. 55, 14513 Teltow, Germany Helmholtz Virtual Institute, Multifunctional Biomaterials for Medicine, Kantstr. 55, 14513 Teltow, Germany Institute of Chemistry, University of Potsdam, 14469 Potsdam, Germany
Christian Wischke
Affiliation:
Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Kantstr. 55, 14513 Teltow, Germany Helmholtz Virtual Institute, Multifunctional Biomaterials for Medicine, Kantstr. 55, 14513 Teltow, Germany
*
*(Email: [email protected])
Get access

Abstract

The microfluidic production of droplets is a well controllable process, which allows templating small spherical containers that can subsequently be transferred into uniformly sized polymer microgel particles by a crosslinking reaction. Recently, the per-channel production rate of N-isopropylacrylamide (NIPAAm) droplets (w-phase) dispersed in a low-viscosity fluorocarbon oil (o-phase) could be increased by a delayed surfactant addition, while maintaining the advantageous dripping regime. Here it should be evaluated, if delayed surfactant addition can be applied to enhance droplet production also for high viscosity continuous phases, which is associated with a change to an inviscid drop scenario compared to the previously used setting of viscous drops. It could be illustrated that the concept of delayed surfactant addition holds true also for viscous continuous phases and allows ∼8 fold increased flow rates in the dripping regime. Surprisingly, the droplet size increased at higher total flow rate with constant flow rate ratios of w- and o-phases, which is discussed in the light of viscous dissipation, microchannel bulging and viscosity of the continuous phase. More rigid microchannels such as from glass may allow further exploring this phenomenon in the future.

Keywords

fluidicsdispersantbiomaterial
Type
Articles
Information
MRS Advances , Volume 1 , Issue 27: Biomaterials and Soft Materials , 2016 , pp. 2019 - 2024
Copyright
Copyright © Materials Research Society 2016 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Baroud, C. N., Gallaire, F. and Dangla, R., Lab Chip 10, 2032 (2010).Google Scholar
Basova, E. Y. and Foret, F., Analyst 140, 22 (2015).Google Scholar
Seiffert, S., Angew Chem Int Edit 52, 11462 (2013).CrossRefGoogle Scholar
Vladisavljević, G. T., Khalid, N., Neves, M. A., Kuroiwa, T., Nakajima, M., Uemura, K., Ichikawa, S. and Kobayashi, I., Advanced Drug Delivery Reviews 65, 1626 (2013).Google Scholar
Seiffert, S., Friess, F., Lendlein, A. and Wischke, C., J Colloid Interface Sci 452, 38 (2015).Google Scholar
Utada, A. S., Fernandez-Nieves, A., Stone, H. A. and Weitz, D. A., Phys Rev Lett 99 (2007).Google Scholar
Ward, T., Faivre, M., Abkarian, M. and Stone, H. A., Electrophoresis 26, 3716 (2005).CrossRefGoogle Scholar
Stan, C. A., Tang, S. K. Y. and Whitesides, G. M., Anal Chem 81, 2399 (2009).CrossRefGoogle Scholar
Koo, J. M. and Kleinstreuer, C., J Micromech Microeng 13, 568 (2003).CrossRefGoogle Scholar
Weigl, B. H., Bardell, R. L. and Cabrera, C., “Introduction to Microfluidic Techniques”, Handbook of Biosensors and Biochips (John Wiley & Sons, Ltd 2008).Google Scholar
Winter, H. H., “Viscous dissipation term in energy equations”, Modular Instruction, Series C: Transport, Volume 7: Calculation and Measurement Techniques for Momentum, Energy, and Mass Transfer, Module C 7.4 ed. Gordon, R. J. (American Institute of Chemical Engineers 1987), pp. 27.Google Scholar
Dangla, R., Gallaire, F. and Baroud, C. N., Lab Chip 10, 2972 (2010).Google Scholar
Holden, M. A., Kumar, S., Beskok, A. and Cremer, P. S., J Micromech Microeng 13, 412 (2003).Google Scholar
Romero, P. A. and Abate, A. R., Lab Chip 12, 5130 (2012).Google Scholar
Cubaud, T., Jose, B. M., Darvishi, S. and Sun, R. P., Int J Multiphas Flow 39, 29 (2012).CrossRefGoogle Scholar