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Tailoring super-hydrophobic properties of electrochemical biosensor for early cancer detection

Published online by Cambridge University Press:  05 August 2016

Natalia Malara ,
Francesco Gentile ,
Lorenzo Ferrara ,
Marco Villani ,
Salvatore Iannotta ,
Andrea Zappettini ,
Enzo Di Fabrizio ,
Valentina Trunzo ,
Vincenzo Mollace  and
Nicola Coppedé
Natalia Malara*
Affiliation:
Department of Health Science, University of Magna Graecia, 88100Catanzaro, Italy Department of Experimental and Clinical Medicine, University of Magna Graecia, 88100Catanzaro, Italy
Francesco Gentile
Affiliation:
Department of Electrical Engineering and Information Technology, University Federico II, Naples, Italy
Lorenzo Ferrara
Affiliation:
Istituto Italiano di Tecnologia, Via Morego 30, 16163Genova, Italy
Marco Villani
Affiliation:
IMEM-CNR Parco Area delle Scienze 37/A - 43124 Parma, Italy
Salvatore Iannotta
Affiliation:
IMEM-CNR Parco Area delle Scienze 37/A - 43124 Parma, Italy
Andrea Zappettini
Affiliation:
IMEM-CNR Parco Area delle Scienze 37/A - 43124 Parma, Italy
Enzo Di Fabrizio
Affiliation:
Department of Experimental and Clinical Medicine, University of Magna Graecia, 88100Catanzaro, Italy King Abdullah University of Science and Technology, Thuwal, Saudi Arabia
Valentina Trunzo
Affiliation:
Department of Health Science, University of Magna Graecia, 88100Catanzaro, Italy
Vincenzo Mollace
Affiliation:
Department of Health Science, University of Magna Graecia, 88100Catanzaro, Italy
Nicola Coppedé
Affiliation:
IMEM-CNR Parco Area delle Scienze 37/A - 43124 Parma, Italy
*
*corresponding author: [email protected]
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Abstract

In this paper, we demonstrate an organic electrochemical transistor (OECT) based on the conductive polymer PEDOT:PSS for the analysis of the cell culture medium upon interaction with circulating cells isolated form peripheral blood sampling of health, sub-clinical and cancer patients. The device comprises arrays of super-hydrophobic micro-pillars in which a finite number of pillars incorporates nano-electrodes for site specific measurements of a solution. Due to its nano-scale architecture, the device realizes time and space resolved measurement of biological solution. Tumor metabolism could produce reactive species able to determine a different electronic behavior of correspondent microenviroment. On this basis, the device here presented the changes in the ESR signals was used to identify electronic changes occurring in the analysis of different type of microenvironment. Our results demonstrate that the device is able to register significative difference to differentiate healthy individuals form cancer patients, through an easy blood sampling. In conclusion, these preliminary data are suggestive of a novel test potentially useful to early identification of subjects at risk to development cancer disease.

Keywords

biomedicaldevicesbiomaterial
Type
Articles
Information
MRS Advances , Volume 1 , Issue 52: Soft Materials and Biomaterials , 2016 , pp. 3545 - 3552
Copyright
Copyright © Materials Research Society 2016 

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References

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