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Influence of 4-vinylbenzylation on the rheological and swellingproperties of photo-activated collagen hydrogels

Published online by Cambridge University Press:  11 December 2015

Giuseppe Tronci ,
Colin A. Grant ,
Neil H. Thomson ,
Stephen J. Russell  and
David J. Wood
Giuseppe Tronci*
Affiliation:
Nonwovens Research Group, Centre for Technical Textiles, School of Design, University of Leeds, Leeds LS2 9JT, United Kingdom School of Dentistry, St. James’s University Hospital, University of Leeds, Leeds LS9 7TF, United Kingdom
Colin A. Grant
Affiliation:
Advanced Materials Engineering, Polymer IRC Labs, Faculty of Engineering & Informatics, University of Bradford, Bradford BD7 1DP, United Kingdom
Neil H. Thomson
Affiliation:
School of Dentistry, St. James’s University Hospital, University of Leeds, Leeds LS9 7TF, United Kingdom Molecular and Nanoscale Physics, School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT, United Kingdom
Stephen J. Russell
Affiliation:
Nonwovens Research Group, Centre for Technical Textiles, School of Design, University of Leeds, Leeds LS2 9JT, United Kingdom
David J. Wood
Affiliation:
School of Dentistry, St. James’s University Hospital, University of Leeds, Leeds LS9 7TF, United Kingdom
*
*(Email: [email protected])
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Abstract

Covalent functionalisation of collagen has been shown to be a promising strategyto adjust the mechanical properties of highly swollen collagen hydrogels. At thesame time, secondary interactions between for example, amino acidic terminationsor introduced functional groups also play an important role and are oftenchallenging to predict and control. To explore this challenge, 4-vinylbenzylchloride (4VBC) and methacrylic anhydride (MA) were reacted with type Icollagen, and the swelling and rheological properties of resultingphoto-activated hydrogel systems investigated. 4VBC-based hydrogels showedsignificantly increased swelling ratio, in light of the lower degree of collagenfunctionalisation, with respect to methacrylated collagen networks, whilstrheological storage moduli were found to be comparable between the two systems.To explore the role of benzyl groups in the mechanical properties of the4VBC-based collagen system, model chemical force microscopy (CFM) was carriedout in aqueous environment with an aromatised probe against an aromatisedgold-coated glass slide. A marked increase in adhesion force(F: 0.11±0.01 nN) was measured between aromatisedsamples, compared to the adhesion force observed between the non-modified probeand a glass substrate (F: 2.64±1.82 nN). These resultssuggest the formation of additional and reversible π-πstacking interactions in aromatic 4VBC-based networks and explain the remarkablerheological properties of this system in comparison to MA-based hydrogels.

Keywords

biomaterialbiomimetic (chemical reaction)nanoscale
Type
Articles
Information
MRS Advances , Volume 1 , Issue 8: Biomaterials and Soft Materials , 2016 , pp. 533 - 538
Copyright
Copyright © Materials Research Society 2015 

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References

REFERENCES

Zhou, T., Wang, N., Xue, Y., Ding, T., Liu, X., Mo, X., Sun, J., ACS Appl. Mater. Interf. 7, 3253–3262 (2015).CrossRefGoogle Scholar
Helary, C., Abed, A., Mosser, G., Louedec, L., Letourneur, D., Coradin, T., Giraud-Guille, M.M., Meddahi-Pellé, A., Biomater. Sci. 3, 373 (2015).CrossRefGoogle Scholar
Sargeant, T.D., Desai, A.P., Banerjee, S., Agawu, A., Stopek, J.B., Acta Biomaterialia 8, 124 (2012).CrossRefGoogle Scholar
Cheng-Hung, C., Yong-Guei, C., Chien-Chen, L., Shang-Ming, L., Kai-Chiang, Y., Shih-Hsin, C., Tissue Eng. Part A, 20, 2493 (2014).Google Scholar
Qiao, X., Russell, S.J., Yang, X., Tronci, G., Wood, D.J., J. Funct. Biomater. 6, 667–686 (2015).CrossRefGoogle Scholar
Tronci, G., Grant, C.A., Thomson, N.H., Russell, S.J., Wood, D.J., J. R. Soc. Interface 12, 20141079 (2015).CrossRefGoogle Scholar
Tronci, G., Russell, S.J., Wood, D.J., J. Mater. Chem. B 1, 3705–3715 (2013).CrossRefGoogle Scholar
Bubnis, W.A., Ofner, C.M., Analyt. Biochem. 207, 129 (1992).CrossRefGoogle Scholar
Hutter, J.L., Bechhoefer, J., Rev. Sci. Instrum. 64, 1868 (1993).CrossRefGoogle Scholar
Noy, A., Daniel Frisbie, C., Rozsnyai, L.F., Wrighton, M.S., Lieber, C.M., J. Am. Chem. Soc. 117, 7943 (1995).CrossRefGoogle Scholar
El-Fiqi, A., Lee, J.H., Lee, E.-J., Kim, H.-W., Acta Biomaterialia 9, 9508 (2013).CrossRefGoogle Scholar
Ding, Y., Li, Y., Qin, M., Cao, Y., Wang, W., Langmuir 29, 13299 (2013).CrossRefGoogle Scholar
Paciello, A., Santonicola, M.G., RSC Adv. 5, 88866 (2015).CrossRefGoogle Scholar
Perutz, M.F., Phil. Trans. R. Soc. A 345, 105 (1993).Google Scholar
Tronci, G., Neffe, A.T., Pierce, B.F., Lendlein, A., J. Mater. Chem. 20, 8875 (2010).CrossRefGoogle Scholar
Barattin, R., Voyer, N., Chem. Commun. 1513 (2008), DOI: 10.1039/B614328H.CrossRefGoogle Scholar