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Diatoms Biosilica as Efficient Drug-Delivery System

Published online by Cambridge University Press:  23 December 2015

Danilo Vona ,
Gabriella Leone ,
Roberta Ragni ,
Fabio Palumbo ,
Antonio Evidente ,
Maurizio Vurro ,
Gianluca M. Farinola  and
Stefania R. Cicco
Danilo Vona
Affiliation:
Dipartimento di Chimica, Università degli Studi di Bari “Aldo Moro”. Via Orabona, 4, 70126 Bari, Italy.
Gabriella Leone
Affiliation:
Dipartimento di Chimica, Università degli Studi di Bari “Aldo Moro”. Via Orabona, 4, 70126 Bari, Italy.
Roberta Ragni
Affiliation:
Dipartimento di Chimica, Università degli Studi di Bari “Aldo Moro”. Via Orabona, 4, 70126 Bari, Italy.
Fabio Palumbo
Affiliation:
CNR NANOTECH, Via Orabona, 4, 70126 Bari, Italy.
Antonio Evidente
Affiliation:
Dipartimento di Scienze Chimiche, Complesso Universitario Monte Sant’Angelo,Via Cintia 4, 80126, Napoli, Italy
Maurizio Vurro
Affiliation:
CNR ISPA, Via Amendola, 122/O, 70125 Bari, Italy.
Gianluca M. Farinola
Affiliation:
Dipartimento di Chimica, Università degli Studi di Bari “Aldo Moro”. Via Orabona, 4, 70126 Bari, Italy.
Stefania R. Cicco*
Affiliation:
CNR ICCOM, Via Orabona, 4, 70126 Bari, Italy
*
*(Email: [email protected])
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Abstract

Diatoms are the most abundant resource of biosilica on Earth. These microalgae are encased in a 3-D amorphous silica “shell” called frustule whose size and morphology is strictly dependent on the diatom species. Naturally nanostructured biosilica from diatoms exhibit unique adsorption and confinement properties useful for delivery of molecules of pharmacological interest.In this work fossil biosilica was used as a carrier for Ophiobolin A (a fungal macrolide with anticancer and antiparasitic properties), with the aim to develop a model system of Ophiobolin A loading / delivery. Ophiobolin A delivery properties of fossil diatoms were investigated by spectophotometric analyses.

Keywords

biomaterialscanning electron microscopy (SEM)Si
Type
Articles
Information
MRS Advances , Volume 1 , Issue 57: Biomaterials and Soft Materials , 2016 , pp. 3825 - 3830
Copyright
Copyright © Materials Research Society 2015 

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References

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