Hostname: page-component-586b7cd67f-t7czq Total loading time: 0 Render date: 2024-11-24T14:46:45.799Z Has data issue: false hasContentIssue false
  • English
  • Français

Copper-free click functionalization of glucose-derived carbon spheres for tumor targeting

Published online by Cambridge University Press:  27 December 2019

Isabel Gessner Open the ORCID record for Isabel Gessner [Opens in a new window] ,
Eva Krakor ,
Sarah Styrnol ,
Annika Klimpel ,
Ines Neundorf  and
Sanjay Mathur
Isabel Gessner
Affiliation:
Institute of Inorganic Chemistry, University of Cologne, Greinstr. 6, 50939 Cologne, Germany
Eva Krakor
Affiliation:
Institute of Inorganic Chemistry, University of Cologne, Greinstr. 6, 50939 Cologne, Germany
Sarah Styrnol
Affiliation:
Institute of Inorganic Chemistry, University of Cologne, Greinstr. 6, 50939 Cologne, Germany
Annika Klimpel
Affiliation:
Institute of Biochemistry, University of Cologne, Zuelpicher Str. 47, 50674 Cologne, Germany
Ines Neundorf
Affiliation:
Institute of Biochemistry, University of Cologne, Zuelpicher Str. 47, 50674 Cologne, Germany
Sanjay Mathur*
Affiliation:
Institute of Inorganic Chemistry, University of Cologne, Greinstr. 6, 50939 Cologne, Germany
*
*corresponding author: [email protected]
Get access

Abstract

The dysfunctional metabolism of glucose in cancer cells represents a new avenue for cancer targeting based on sugar-derived carriers. Here, glucose-derived carbon spheres (CS) were prepared through a simple hydrothermal method, yielding highly homogenous spherical particles that exhibited excellent stability in aqueous solution. The abundant presence of surface hydroxyl functionalities was used for a subsequent condensation of an amino silane that was the basis for further covalent coupling strategies. CS were modified with a cyclooctyne derivative providing a highly selective binding site for copper-free click reactions. Moreover, the surface modification of CS with a dye-label allowed for their intracellular detection revealing a preferential uptake of CS, compared to silica particles, in tumor cells. These results thus demonstrate the highly promising potential of glucose-derived particles for tumor targeting applications and their efficient surface modification.

Keywords

biomedicalbiomaterialhydrothermalsurface chemistrytissue
Type
Articles
Information
MRS Advances , Volume 4 , Issue 53: International Materials Research Congress XXVIII , 2019 , pp. 2881 - 2887
Copyright
Copyright © Materials Research Society 2019 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Hanahan, D., Weinberg, R. A., Cell 144, 646–674, (2011).CrossRefGoogle Scholar
Gillies, R. J., Robey, I., Gatenby, R. A., J. Nucl. Med. 49, 24–43, (2008).CrossRefGoogle Scholar
Zhao, S., Kuge, Y., Mochizuki, T., Takahashi, T., J. Nucl. Med. 46, 675–683, (2005).Google Scholar
Calvaresia, E. C., Hergenrother, P. J., Chem. Sci. 4, 2319–2333, (2013).CrossRefGoogle Scholar
Venturelli, L., Nappini, S., Bulfon, M., Gianfranceschi, G., Zilio, S. D., Coceano, G., Del Ben, F., Turetta, M., Scoles, G., Vaccari, L., et al. , Sci. Rep. 6, 21629, (2016).CrossRefGoogle Scholar
Gessner, I., Mathur, S., in Nanotechnologies Prev. Regen. Med. (Ed.: Uskovic, V.), Elsevier Ltd, Oxford, (2018), pp. 260–297.Google Scholar
Becer, C. R., Hoogenboom, R., Schubert, U. S., Angew. Chemie (International ed. ) 48, 4900–4908, (2009).CrossRefGoogle Scholar
Bhagat, P. N., Patil, K. R., Bodas, D. S., Paknikar, K. M., RSC Adv . 5, 59491–59494, (2015).CrossRefGoogle Scholar
Andón, F. T., Mukherjee, S. P., Gessner, I., Wortmann, L., Xiao, L., Hultenby, K., Shvedova, A. A., Mathur, S., Fadeel, B., Carbon N. Y. 113, 243–251, (2017).CrossRefGoogle Scholar
Sun, X., Li, Y., Angew. Chem. Int. Ed. 43, 597–601, (2004).CrossRefGoogle Scholar
Fu, Y., Liu, S., Yin, S., Niu, W., Xiong, W., Oncotarget 8, 57813–57825, (2017).Google Scholar
Gessner, I., Krakor, E., Jurewicz, A., Wulff, V., Kling, L., Christiansen, S., Brodusch, N., Gauvin, R., Wortmann, L., Wolke, M., et al. , RSC Adv . 8, 24883–24892, (2018).CrossRefGoogle Scholar