Hostname: page-component-586b7cd67f-t8hqh Total loading time: 0 Render date: 2024-12-01T02:53:39.906Z Has data issue: false hasContentIssue false
  • English
  • Français

Structure and Properties in Synthetic MSUM and the Corresponding Biomaterial

Published online by Cambridge University Press:  28 June 2016

Alicia B. Brune ,
Gregory P. Holland ,
Jeffery L. Yarger  and
William T. Petuskey
Alicia B. Brune*
Affiliation:
School of Molecular Sciences, Arizona State University, Tempe, AZ, United States.
Gregory P. Holland
Affiliation:
Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA, United States.
Jeffery L. Yarger
Affiliation:
School of Molecular Sciences, Arizona State University, Tempe, AZ, United States.
William T. Petuskey
Affiliation:
School of Molecular Sciences, Arizona State University, Tempe, AZ, United States.
*
*(Email: [email protected])
Get access

Abstract

At the MRS Fall 2014 Meeting, Symposium E, we reported on morphologies, fragmentation, and hardness in synthetic hydrogen urate monohydrate (monosodium urate monohydrate, MSUM, or MSU) crystals. We are now presenting further characterization results, including some from the biomaterial that forms in humans with gout disease: The fanning of radiating blades (needles) in spherulitic grains of synthetic MSUM was examined by microscopy techniques. These and previous data are consistent with an interpretation in terms of the crystallographic parameters in the unit cell, and the presence of dislocation arrays at low angle boundaries. The kinetics of such branched growth is here related to thermodynamic properties and super-saturation levels. Secondary nucleation is an additional mechanism leading to more complex morphologies. Differences in overall growth rates, under conditions of either branched or single needle growth, are considered in relation to gout. Novel powder XRD and solid state NMR data show, respectively, preferred orientation in the biomaterial, and the potential of NMR for identifying and characterizing MSUM in specific environments, helping to resolve pending questions in gout. Present results are anticipated to be useful for designing bio-inspired and bio-mimetic materials, regarding morphologies, overall growth rates, and mechanical properties.

Keywords

biomedicalcrystal growthdislocations
Type
Articles
Information
MRS Advances , Volume 1 , Issue 36: Soft Materials and Biomaterials , 2016 , pp. 2551 - 2556
Copyright
Copyright © Materials Research Society 2016 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Fiechtner, J.J., and Simkin, P.A., J. American Medical Association 245, 1533 (1981).Google Scholar
Fam, A.G., Schumacher, H.R. Jr., Clayburne, G., Sieck, M., Mandel, N.S., Cheng, P-T. and Pritzker, K.P.H., The Journal of Rheumatology 19, 780 (1992).Google Scholar
Pascual, E., Addadi, L., Andrés, M. and Sivera, F., Nature Reviews. Rheumatology 11, 725 (2015).Google Scholar
Brune, A. B. and Petuskey, W.T., MRS Proceedings 1721, mrsf14-1721-e05-09 doi:10.1557/opl.2015.11.Google Scholar
Chhana, A., Lee, G. and Dalbeth, N., BMC Musculoskeletal Disorders 16, 296 (2015).Google Scholar
Calvert, P.D., Fiddis, R.W. and Vlachos, N., Colloids and Surfaces 14, 97 (1985).Google Scholar
Burt, H.M. and Dutt, Y.C., J. Crystal Growth 94, 15 (1989).CrossRefGoogle Scholar
Puel, F., Verdurand, E., Taulelle, P., Bebon, C., Colson, D., Klein, J-P. and Vessler, S, J. Crystal Growth 310, 110 (2008).CrossRefGoogle Scholar
Perrin, C.M., Dobish, M., Van Keurenb, E. and Swift, J.A., CrystEngComm 13, 1111 (2011).Google Scholar
Burgers, J. M., Proc. Phys. Soc. (London) 52, 23 (1940).Google Scholar
Knowles, K.M., Butt, H., Batal, A., Sabouri, A. and Anthony, C.J., Optical Materials 56, 163 (2016).Google Scholar
Uhlmann, D.R. and Uhlmann, E.V., Ceramic Transactions 30, 109 (1993).Google Scholar
Howell, R.R., Eanes, E.D. and Seegmiller, J.E., Arthritis and Rheumatism 6, 97 (1963).Google Scholar
Schubert, G., Reck, G., Jancke, H., Kraus, W. and Patzelt, C., Urol. Res. 33, 231(2005).Google Scholar
Coxon, B., Fatiadi, A.J., Sniegoski, L.T., Hertz, H.S. and Schaffer, R., J. Org. Chem. 42, 3132 (1977).CrossRefGoogle Scholar
McGill, N., Dieppe, P.A., Bowden, M., Gardiner, D.J. and Hall, M., The Lancet 337, 77 (1991).Google Scholar