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Sintered Tape-cast 3YSZ Supports Human Bone Marrow Derived Stem Cell Osteogenic Differentiation

Published online by Cambridge University Press:  02 September 2019

Alexander K. Nguyen Open the ORCID record for Alexander K. Nguyen [Opens in a new window] ,
Peter L. Goering ,
John A. Olenick ,
Kathy Olenick  and
Roger J. Narayan
Alexander K. Nguyen
Affiliation:
North Carolina State University, UNC/NCSU Joint Department of Biomedical Engineering, 911 Oval Drive, Raleigh, NC27695 US Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Division of Biology, Chemistry, and Materials Science, 10903 New Hampshire Ave., Silver Spring, MD20993
Peter L. Goering
Affiliation:
US Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Division of Biology, Chemistry, and Materials Science, 10903 New Hampshire Ave., Silver Spring, MD20993
John A. Olenick
Affiliation:
ENrG Inc., Buffalo, NY14207
Kathy Olenick
Affiliation:
ENrG Inc., Buffalo, NY14207
Roger J. Narayan*
Affiliation:
North Carolina State University, UNC/NCSU Joint Department of Biomedical Engineering, 911 Oval Drive, Raleigh, NC27695
*
*(Email: [email protected])
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Abstract

Sintered tape-cast yttria-stabilized zirconia (YSZ) was evaluated for its elemental composition, crystal structure, and imaged with atomic force microscopy (AFM) and scanning electron microscopy (SEM). Human bone marrow stem cells (hBMSC) were cultured on the ceramic and differentiated into the osteoblast lineage; alkaline phosphatase (ALP) activity was tracked as a differentiation marker. The YSZ was composed of purely tetragonal grains with a median equivalent circular diameter of 283 nm. Zirconium, yttrium, oxygen, and adventitious carbon was detected on the substrate with no other elements in significant quantities detected. YSZ samples had an RMS roughness value of 27 nm, elastic modulus of 206 ± 14 GPa, and hardness of 14 ± 2 GPa. hBMSC were observed to attach and proliferate on the YSZ surfaces and had significantly increased ALP versus the undifferentiated control cultured on glass. This method for producing a YSZ ceramic yields a typical material of this type and supports attachment and differentiation of hBMSC; thus, making it useful as a bone implant material.

Keywords

biomaterialceramicnano-indentationbone
Type
Articles
Information
MRS Advances , Volume 4 , Issue 46-47: Soft Materials and Biomaterials , 2019 , pp. 2541 - 2549
Copyright
Copyright © Materials Research Society 2019 

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References

References:

Takamura, K., Hayashi, K., Ishinishi, N., Yamada, T., and Sugioka, Y., J. Biomed. Mater. Res. 28 (5), 583-589. (1994)CrossRefGoogle Scholar
Covacci, V., Bruzzese, N., Maccauro, G., Andreassi, C., Ricci, G.A., Piconi, C., Marmo, E., Burger, W., and Cittadini, A., Biomaterials. 20 (4), 371-376. (1999)CrossRefGoogle Scholar
Stout, M.M., Cook, B.K., Arola, D.D., Fong, H., Raigrodski, A.J., and Bollen, A.M., Am J Orthod Dentofacial Orthop. 151 (1), 63-73. (2017)CrossRefGoogle Scholar
Ardlin, B.I., Dental Materials. 18 (8), 590-595. (2002)CrossRefGoogle Scholar
Cales, B., Clin Orthop Relat Res . 379, 94-112. (2000)CrossRefGoogle Scholar
Berni, M., Lopomo, N., Marchiori, G., Gambardella, A., Boi, M., Bianchi, M., Visani, A., Pavan, P., Russo, A., and Marcacci, M., Materials Science and Engineering: C. 62, 643-655. (2016)CrossRefGoogle Scholar
Masonis, J.L., Bourne, R.B., Ries, M.D., McCalden, R.W., Salehi, A., and Kelman, D.C., The Journal of Arthroplasty. 19 (7), 898-905. (2004)CrossRefGoogle Scholar
Scott, H.G., Journal of Materials Science. 10 (9), 1527-1535. (1975)CrossRefGoogle Scholar
Chevalier, J., Deville, S., Münch, E., Jullian, R., and Lair, F., Biomaterials. 25 (24), 5539-5545. (2004)CrossRefGoogle Scholar
Kim, S.H., Singh, S., Oh, S.K., Lee, D.K., Lee, K.H., Shervin, S., Asadirad, M., Venkateswaran, V., Olenick, K., Olenick, J.A., Lee, S., Kwak, J.S., Mavrokefalos, A., and Ryou, J., IEEE Electron Device Letters. 37 (5), 615-617. (2016)CrossRefGoogle Scholar
Gopalan, K.K., Rodrigo, D., Paulillo, B., Soni, K.K., and Pruneri, V., Advanced Optical Materials. 7 (2), 1800966. (2019)CrossRefGoogle Scholar
Burlingame, N., Accelerated Life Testing of Thin Ceramic Substrates. 2014(unpublished work).Google Scholar
Heshmatpour, F., Khodaiy, Z., and Aghakhanpour, R.B., Powder Technology. 224, 12-18. (2012)CrossRefGoogle Scholar
Viazzi, C., Bonino, J.-P., Ansart, F., and Barnabé, A., Journal of Alloys and Compounds. 452 (2), 377-383. (2008)CrossRefGoogle Scholar
Barad, C., Shekel, G., Shandalov, M., Hayun, H., Kimmel, G., Shamir, D., and Gelbstein, Y., Materials. 10 (12), 1440. (2017)CrossRefGoogle Scholar
Moulder, J., Stickle, W., Sobol, P., and Bomben, K., Handbook of X-ray Photoelectron Spectroscopy, ed. Chastain, J.. (Perkin-Elmer Corporation, Eden Prarie, Minnesota, 1992).Google Scholar
Adams, J.W., Ruh, R., and Mazdiyasni, K.S., Journal of the American Ceramic Society. 80 (4), 903-908. (1997)CrossRefGoogle Scholar
Stollberg, D.W., Hampikian, J.M., Riester, L., and Carter, W.B., Materials Science and Engineering: A. 359 (1), 112-118. (2003)CrossRefGoogle Scholar
Tong, H., Tanaka, C.B., Kaizer, M.R., and Zhang, Y., Ceramics international. 42 (1 Pt B), 1077-1085. (2016)CrossRefGoogle Scholar
E Golub, E. and Boesze-Battaglia, K., Current Opinion in Orthopedics. 18 (5), 444-448. (2007)CrossRefGoogle Scholar