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Seed-mediated synthesis and PEG coating of gold nanoparticles for controlling morphology and sizes

Published online by Cambridge University Press:  26 November 2020

Susana Helena Arellano Ramírez ,
Perla García Casillas  and
Christian Chapa González Open the ORCID record for Christian Chapa González [Opens in a new window]
Susana Helena Arellano Ramírez
Affiliation:
Institute of Biomedical Sciences, Autonomous University of Ciudad Juárez, Nanomedicine-UACJ, Ciudad Juárez, 32310, México
Perla García Casillas
Affiliation:
Institute of Engineering and Technology Autonomous University of Ciudad Juárez, Nanomedicine-UACJ Ciudad Juárez, 32310, México
Christian Chapa González*
Affiliation:
Institute of Engineering and Technology Autonomous University of Ciudad Juárez, Nanomedicine-UACJ Ciudad Juárez, 32310, México
*
[email protected]
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Abstract

A significant area of research is biomedical applications of nanoparticles which involves efforts to control the physicochemical properties through simple and scalable processes. Gold nanoparticles have received considerable attention due to their unique properties that they exhibit based on their morphology. Gold nanospheres (AuNSs) and nanorods (AuNRs) were prepared with a seed-mediated method followed of polyethylene glycol (PEG)-coating. The seeds were prepared with 0.1 M cetyltrimethyl-ammonium bromide (CTAB), 0.005 M chloroauric acid (HAuCl4), and 0.01 M sodium borohydride (NaBH4) solution. Gold nanoparticles with spherical morphology was achieved by growth by aggregation at room temperature, while to achieve the rod morphology 0.1 M silver nitrate (AgNO3) and 0.1 M ascorbic acid solution were added. The gold nanoparticles obtained by the seed-mediated synthesis have spherical or rod shapes, depending on the experimental conditions, and a uniform particle size. Surface functionalization was developed using polyethylene glycol. Morphology, and size distribution of AuNPs were evaluated by Field Emission Scanning Electron Microscopy. The average size of AuNSs, and AuNRs was 7.85nm and 7.96 x 31.47nm respectively. Fourier transform infrared spectrometry was performed to corroborate the presence of PEG in the AuNPs surface. Additionally, suspensions of AuNSs and AuNRs were evaluated by UV-Vis spectroscopy. Gold nanoparticles were stored for several days at room temperature and it was observed that the colloidal stability increased once gold nanoparticles were coated with PEG due to the shield formed in the surface of the NPs and the increase in size which were 9.65±1.90 nm of diameter for AuNSs and for AuNRs were 29.03±5.88 and 8.39±1.02 nm for length and transverse axis, respectively.

Type
Articles
Information
MRS Advances , Volume 5 , Issue 63: International Materials Research Congress XXIX , 2020 , pp. 3353 - 3360
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Copyright
Copyright © The Author(s), 2020, published on behalf of Materials Research Society by Cambridge University Press

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References

Jeon, S. and Jeon, H., “Doxorubicin-loaded oligonucleotide conjugated gold nanoparticles: A promising drug delivery system for ovarian cancer,” Gynecol. Oncol., vol. 159, p. 117, Oct. 2020.CrossRefGoogle Scholar
Yang, W., Liang, H., Ma, S., Wang, D., and Huang, J., “Gold nanoparticle based photothermal therapy: Development and application for effective cancer treatment,” Sustainable Materials and Technologies, vol. 22. Elsevier B.V., p. e00109, 01-Dec-2019.Google Scholar
Nekounam, H., Allahyari, Z., Gholizadeh, S., Mirzaei, E., Shokrgozar, M. A., and Faridi-Majidi, R., “Simple and robust fabrication and characterization of conductive carbonized nanofibers loaded with gold nanoparticles for bone tissue engineering applications,” Mater. Sci. Eng. C, vol. 117, p. 111226, Dec. 2020.CrossRefGoogle ScholarPubMed
Zhang, L., Mazouzi, Y., Salmain, M., Liedberg, B., and Boujday, S., “Antibody-Gold Nanoparticle Bioconjugates for Biosensors: Synthesis, Characterization and Selected Applications,” Biosens. Bioelectron., vol. 165, no. 1, p. 112370, Oct. 2020.CrossRefGoogle ScholarPubMed
Flores, V. G., “Endocytosis and exocytosis processes of gold nanoparticle with erythrocyte ghosts,” MRS Adv., vol. 5, no. 42, pp. 2169–2172, 2020.CrossRefGoogle Scholar
Huang, H. et al. , “Continuous flow synthesis of ultrasmall gold nanoparticles in a microreactor using trisodium citrate and their SERS performance,” Chem. Eng. Sci., vol. 189, pp. 422–430, Nov. 2018.10.1016/j.ces.2018.06.050CrossRefGoogle Scholar
Daruich De Souza, C., Ribeiro Nogueira, B., and Rostelato, M. E. C. M., “Review of the methodologies used in the synthesis gold nanoparticles by chemical reduction,” Journal of Alloys and Compounds, vol. 798. Elsevier Ltd, pp. 714–740, 25-Aug-2019.CrossRefGoogle Scholar
Zhou, J., Ralston, J., Sedev, R., and Beattie, D. A., “Functionalized gold nanoparticles: Synthesis, structure and colloid stability,” J. Colloid Interface Sci., vol. 331, no. 2, pp. 251–262, 2009.10.1016/j.jcis.2008.12.002CrossRefGoogle ScholarPubMed
Kraynov, A. and Muller, T. E., “Concepts for the Stabilization of Metal Nanoparticles in Ionic Liquids,” Appl. Ion. Liq. Sci. Technol., pp. 235–260, 2011.Google Scholar
Fjordbøge, A. S., Uthuppu, B., Jakobsen, M. H., Fischer, S. V., and Broholm, M. M., “Mobility of electrostatically and sterically stabilized gold nanoparticles (AuNPs) in saturated porous media,” Environ. Sci. Pollut. Res., 2019.CrossRefGoogle Scholar
Petry, R. et al. , “On the formation of protein corona on colloidal nanoparticles stabilized by depletant polymers,” Mater. Sci. Eng. C, vol. 105, p. 110080, 2019.CrossRefGoogle ScholarPubMed
Franconetti, A., Carnerero, J. M., Prado-Gotor, R., Cabrera-Escribano, F., and Jaime, C., “Chitosan as a capping agent: Insights on the stabilization of gold nanoparticles,” Carbohydr. Polym., vol. 207, pp. 806–814, 2019.CrossRefGoogle ScholarPubMed
Esquivel, R. et al. , “Poly(N-isopropylacrylamide)-coated gold nanorods mediated by thiolated chitosan layer: Thermo-pH responsiveness and optical properties,” E-Polymers, vol. 18, no. 2, pp. 163–174, Feb. 2018.CrossRefGoogle Scholar
Tovar-Cabrera, S. A. et al. , “Hollow Gold Nanoshells Encapsulated in PNIPAM Nanoparticles,” Microsc. Microanal., vol. 24, no. S1, pp. 1794–1795, Aug. 2018.CrossRefGoogle Scholar
López-Millán, A. et al. , “Aqueous-Organic Phase Transfer of Gold and Silver Nanoparticles Using Thiol-Modified Oleic Acid,” Appl. Sci., vol. 7, no. 3, p. 273, Mar. 2017.10.3390/app7030273CrossRefGoogle Scholar
Chapa-González, C., Piñón-Urbina, A. L., and García-Casillas, P. E., “Synthesis of controlled-size silica nanoparticles from sodium metasilicate and the effect of the addition of PEG in the size distribution,” Materials (Basel )., vol. 11, no. 4, Mar. 2018.Google ScholarPubMed
Lickmichand, M. et al. , “In vitro biocompatibility and hyperthermia studies on synthesized cobalt ferrite nanoparticles encapsulated with polyethylene glycol for biomedical applications,” in Materials Today: Proceedings, 2019, vol. 15, pp. 252–261.Google Scholar
Rabanel, J. M., Piec, P. A., Landri, S., Patten, S. A., and Ramassamy, C., “Transport of PEGylated-PLA nanoparticles across a blood brain barrier model, entry into neuronal cells and in vivo brain bioavailability,” J. Control. Release, vol. 328, pp. 679–695, Dec. 2020.CrossRefGoogle ScholarPubMed
Cao, Z. et al. , “Enhanced colloidal stability and protein resistance of layered double hydroxide nanoparticles with phosphonic acid-terminated PEG coating for drug delivery,” J. Colloid Interface Sci., vol. 521, pp. 242–251, Jul. 2018.CrossRefGoogle ScholarPubMed
Afrooz, A. R. M. N., Sivalapalan, S. T., Murphy, C. J., Hussain, S. M., Schlager, J. J., and Saleh, N. B., “Spheres vs. rods: The shape of gold nanoparticles influences aggregation and deposition behavior,” Chemosphere, vol. 91, no. 1, pp. 93–98, 2013.10.1016/j.chemosphere.2012.11.031CrossRefGoogle ScholarPubMed
Elahi, N., Kamali, M., and Baghersad, M. H., “Recent biomedical applications of gold nanoparticles: A review,” Talanta, vol. 184, no. 2018, pp. 537–556, Jul. 2018.CrossRefGoogle ScholarPubMed
Dykman, L. A., Staroverov, S. A., Fomin, A. S., Khanadeev, V. A., Khlebtsov, B. N., and Bogatyrev, V. A., “Gold nanoparticles as an adjuvant: Influence of size, shape, and technique of combination with CpG on antibody production,” Int. Immunopharmacol., vol. 54, pp. 163–168, 2018.CrossRefGoogle ScholarPubMed
Kumari, Y. et al. , “Gold nanoparticles: New routes across old boundaries,” Adv. Colloid Interface Sci., vol. 274, p. 102037, 2019.CrossRefGoogle ScholarPubMed
Nikoobakht, B. and El-Sayed, M. A., “Preparation and Growth Mechanism of Gold Nanorods (NRs) Using Seed-Mediated Growth Method,” Chem. Mater., vol. 15, no. 10, pp. 1957–1962, Apr. 2003.CrossRefGoogle Scholar