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Radiopaque and biodegradable beads fabricated with Lipiodol and polycaprolactone for transarterial chemoembolization

Published online by Cambridge University Press:  15 February 2019

Yutaka Okamoto ,
Kenta Bito ,
Terumitsu Hasebe ,
Tomohiro Matsumoto  and
Atsushi Hotta
Yutaka Okamoto
Affiliation:
Department of Mechanical Engineering, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama223-8522, Japan
Kenta Bito
Affiliation:
Department of Mechanical Engineering, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama223-8522, Japan
Terumitsu Hasebe
Affiliation:
Department of Mechanical Engineering, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama223-8522, Japan Department of Radiology, Tokai University Hachioji Hospital, Tokai University School of Medicine, 1838 Ishikawa-cho, Hachioji-shi, Tokyo192-0032, Japan
Tomohiro Matsumoto
Affiliation:
Department of Mechanical Engineering, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama223-8522, Japan Department of Radiology, Tokai University Hachioji Hospital, Tokai University School of Medicine, 1838 Ishikawa-cho, Hachioji-shi, Tokyo192-0032, Japan
Atsushi Hotta*
Affiliation:
Department of Mechanical Engineering, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama223-8522, Japan
*
#Corresponding author: [email protected]
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Abstract

Embolic beads for transarterial chemoembolization (TACE) should possess radiopacity and biodegradability at the same time, to be visualized in a body under fluoroscopy and CT scanning to avoid complicating disease. In this study, we fabricated radiopaque and biodegradable beads composed of Lipiodol (LPD) (ethiodized oil) and polycaprolactone (PCL), a biocompatible and biodegradable polymer. LPD/PCL beads were first fabricated with a home-made microfluidic device. By changing the flow-rate ratio in the microfluidic device, the mean diameter of LPD/PCL beads could be well controlled. The radiopacity was evaluated by the fluoroscopic imaging and the CT number measurements. Furthermore, the biodegradability was evaluated by collecting the weight loss data of LPD/PCL immersed in lipase/PBS solution and PBS. The results showed that LPD/PCL beads obtained in this study had sufficient radiopacity and biodegradability, which would be an alternative embolic agent for TACE.

Keywords

biomaterialmicroscaleblendpolymerx-ray fluorescence
Type
Articles
Information
MRS Advances , Volume 4 , Issue 20: Biomaterials and Soft Materials , 2019 , pp. 1187 - 1192
Copyright
Copyright © Materials Research Society 2019 

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Footnotes

*

These authors contributed equally to this paper.

References

Duran, R., Sharma, K., Dreher, M. R., Ashrafi, K., Mirpour, S., Lin, M., Schernthaner, R. E., Schlachter, T. R., Tacher, V., Lewis, A. L., Willis, S., Hartog, M., Radaelli, A., Negussie, A. H., Wood, B. J., Geschwind, J. H., Theranostics 6, 28-39 (2016).CrossRefGoogle Scholar
Yadav, A. V., Mote, H. H., Indian J. Pharm. Sci. 70, 170-174 (2008).CrossRefGoogle Scholar
Woei, K., Hutmacher, D. W., Schantz, J. T., Seng, C., Too, H. P., Chye, T., Phan, T. T. and Teoh, S. H., Tissue Eng . 7, 441-455 (2001).Google Scholar
Miyai, T., Ito, A., Tamazawa, G., Matsuno, T., Sogo, Y., Nakamura, C., Yamazaki, A. and Satoh, T., Biomaterials 29, 350-358 (2008).CrossRefGoogle Scholar
Bouquey, M., Serra, C., Berton, N., Prat, L. and Hadziioannou, G., Chem. Eng. J. 135, S93-S98 (2008).CrossRefGoogle Scholar
Ashrafi, K., Tang, Y., Britton, H., Domenge, O., Blino, D., Brushby, A. J., Shuturminska, K., Hartog, M., Radaelli, A., Negussie, A. H., Mikhail, A. S., Woods, D. L., Krishnasamy, V., Levy, E. B., Wood, B. J., Willis, S. L., Dreher, M. R., Lewis, A. L., J. Controlled Release. 250, 36-47 (2017).CrossRefGoogle Scholar
Li, S., Garreau, H., Pauvert, B., McGrath, J., Toniolo, A. and Vert, M., Biomacromolecules 3, 525-530 (2002).CrossRefGoogle Scholar
Blaine, G., Lancet . 2, 427-429 (1951).CrossRefGoogle Scholar