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Preparation of Macroporous Carboxymethyl Cellulose Cryogels and Its Blood Compatibility

Published online by Cambridge University Press:  27 December 2019

Nurettin Saniner Open the ORCID record for Nurettin Saniner [Opens in a new window] ,
Selin S. Suner  and
Murat Tosunoglu
Nurettin Saniner*
Affiliation:
Department of Chemistry, Faculty of Science & Arts, and Nanoscience and Technology Research and Application Center (NANORAC) Canakkale Onsekiz Mart University, Terzioglu Campus, 17100, Canakkale, Turkey. Department of Ophthalmology, School of Medicine, University of South Florida, Eye Institute,12901 Bruce B. Downs Blvd., Tampa, FL, 33612, USA.
Selin S. Suner
Affiliation:
Department of Chemistry, Faculty of Science & Arts, and Nanoscience and Technology Research and Application Center (NANORAC) Canakkale Onsekiz Mart University, Terzioglu Campus, 17100, Canakkale, Turkey.
Murat Tosunoglu
Affiliation:
Department of Biology, Faculty of Science & Arts, Canakkale Onsekiz Mart University, Terzioglu Campus, 17100, Canakkale, Turkey.
*
*(Email: [email protected])
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Abstract

Superporous Carboxy Methyl Cellulose (CMC) cryogels were synthesized by chemical crosslinking of linear CMC with divinyl sulfone (DVS) with different mole ratios of CMC repeating unit down to 2.5%. The morphology of macroporous CMC cryogels was visualized by optic microscope and scanning electron microscope (SEM) images. The swelling capacity and pore volume of CMC cryogels were found to increase with the decrease in the ratio of crosslinker to CMC, and the highest swelling capacity and pore volume values were 10825±1799% and 22.1±0.4 mL/g for 2.5% mole ratio of crosslinked CMC cryogels. The blood compatibility of CMC cryogels revealed that blood cells were destroyed with very low hemolysis ratio of 1.09±1% and also showed less thrombogenic activity with 80.2±5.1% blood clotting indexes.

Keywords

microstructurebiomaterialporosity
Type
Articles
Information
MRS Advances , Volume 5 , Issue 16: Soft Materials and Biomaterials , 2020 , pp. 825 - 833
Copyright
Copyright © Materials Research Society 2019

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