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Laser Application of Nanocomposite Hydrogels on Cancer Cell Viability

Published online by Cambridge University Press:  17 April 2020

Y. Danyuo ,
A. A. Salifu ,
J. D. Obayemi ,
C. J. Ani ,
S. Dozie-Nwachukwu ,
Theresa Ezenwafor  and
J. Yirijor
Y. Danyuo*
Affiliation:
Department of Mechanical Engineering, Ashesi University, Berekuso, Ghana Department of Materials Science and Engineering, African University of Science and Technology, Federal Capital Territory, Abuja, Nigeria
A. A. Salifu
Affiliation:
Department of Mechanical Engineering, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA 01609, USA.
J. D. Obayemi
Affiliation:
Department of Mechanical Engineering, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA 01609, USA.
C. J. Ani
Affiliation:
Department of Theoretical and Applied Physics, African University of Science and Technology (AUST), Km 10, Airport Road, Federal Capital Territory, Abuja Nigeria
S. Dozie-Nwachukwu
Affiliation:
Biotechnology Advance Research Center, Sheda Science and Technology Complex (SHESTCO), Abuja, Federal Capital Territory, Nigeria
Theresa Ezenwafor
Affiliation:
Department of Materials Science and Engineering, African University of Science and Technology, Federal Capital Territory, Abuja, Nigeria
J. Yirijor
Affiliation:
Academic City College, Department of Mechanical Engineering, Haatso-Accra, Ghana
*
*Corresponding Author: Email: [email protected], Mobile: +233550505434.
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Abstract

Nanocomposite hydrogels of poly-n-isopropyl were prepared by incorporating gold and magnetite nanoparticles. The nanocomposite-based hydrogels formed were geometrical, ∼7.3 mm in diameter and 5 mm thick (in the swollen state). Morphological analysis was characterized by a scanning electron microscope. Drug-loaded hydrogels were subjected to laser heating at 1 W, 1.5 W and 2 W for 20 min in each laser cycle. The metabolic activities of the cells were analysed. The photothermal conversion efficiency of the nanocomposite hydrogels was also evaluated for P(NIPA)-AuNP-PG and P(NIPA)-MNP-PG to be 36.93 and 32.57 %, respectively. The result was then discussed for potential applications whereby metal-based hydrogels can be employed in microfluidic devices for targeted cancer drug delivery.

Keywords

biomaterialdeviceslaser ablationmagnetic propertiespolymerization
Type
Articles
Information
MRS Advances , Volume 5 , Issue 26: African Materials Research Society 2019 , 2020 , pp. 1377 - 1385
Copyright
Copyright © Materials Research Society 2020

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References

Levaggi, A., Poggio, F., and Lambertini, M. (2014). The burden of breast cancer from China to Italy. Journal of Thoracic Disease, 6(6), 591-594.Google ScholarPubMed
Zhang, W., Becciolini, A., Biggeri, A., Pacini, P., and Muirhead, C. R.Second malignancies in breast cancer patients following radiotherapy: a study in Florence, Italy. Breast Cancer Research. (2011).CrossRefGoogle Scholar
Shachar, S. S. and Muss, H. B.Assessing Treatment Response in Metastatic Breast Cancer. American Journal of Hematology/Oncology, 12(6) (2016) 6-10.Google Scholar
Madani, S. Y., Naderi, N., Dissanayake, O., Tan, A., & Seifalian, A. M. (2011). A new era of cancer treatment: Carbon nanotubes as drug delivery tools. International Journal of Nanomedicine, 6 (2011) (2963-2979).Google ScholarPubMed
Danyuo, Y., Obayemi, J. D., Dozie-nwachukwu, S., Ani, C. J., Odusanya, O. S., Oni, Y., and Anuku, N.Prodigiosin release from an implantable biomedical device: kinetics of localized cancer drug release. Mater. Sci. and Engr. C, 42 (2014) 734-745.CrossRefGoogle ScholarPubMed
Oni, Y., Theriault, C., Hoek, A. V. and Soboyejo, W. O.Effects of Temperature on Diffusion from PNIPA-Based Gels in a BioMEMS Device for Localized Chemotherapy and Hyperthermia. Mater. Sci. Eng. C 31(2011) 67-76.CrossRefGoogle Scholar
Zhang, J., Cheng, S., Huang, S. and Zhuo, R.Temperature-Sensitive Poly (N -isopropylacrylamide) Hydrogels with Macroporous Structure and Fast Response Rate. Macromol. Rapid Commun. 24 (2003) 447-451.CrossRefGoogle Scholar
Danyuo, Y., Dozie-Nwachukwu, S., Obayemi, J. D., Ani, C. J., Odusanya, O. S., Oni, Y., Anuku, N., Malatesta, K. and Soboyejo, W. O.Swelling of Poly (N-isopropyl acrylamide) (PNIPA)-Based Hydrogels with Bacterial-Synthesized Prodigiosin for Localized Cancer Drug Delivery. Mater. Sci. and Engr. C (MSEC) 59 (2016) 19-29.CrossRefGoogle Scholar
Danyuo, Y., Ani, C. J., Salifu, A. A., Obayemi, J. D., Dozie-Nwachukwu, S., Obanawu, V. O., Akpan, U. M., Odusanya, O. S., Abade-Abugre, M., McBagonluri, F. and Soboyejo, W. O.Anomalous Release Kinetics of Prodigiosin from Poly-N-Isopropyl-Acrylamid based Hydrogels for The Treatment of Triple Negative Breast Cancer. Scientific Reports. 9 (2019) 3862.CrossRefGoogle ScholarPubMed
Obayemi, J. D., Dozie-Nwachukwu, S., Danyuo, Y., Odusanya, O. S., Anuku, N., Malatesta, K. and Soboyejo, W. O.Biosynthesis and the Conjugation of Magnetite Nanoparticles with Luteinizing Hormone Releasing Hormone (LHRH). ELSEVIER; Materials Science and Engineering C (MSEC). 46 (2015) 482-496.Google Scholar
Dozie-Nwachukwu, S. O., Obayemi, J. D., Danyuo, Y., Etuk-Udo, G., Anuku, N., Odusanya, O.S., Malatesta, K., Chi, C.and Soboyejo, W.O.Advanced Materials for Sustainable Development. Editors: Soboyejo, W., Odusanya, S., Kana, Z., Anukwu, N., Malatesta, K. and Dauda, M.. Biosynthesis of Gold Nanoparticles with Serratia marcescens Bacteria. Trans Tech Publications, Switzerland. Book of proceedings. 1132 (2016) 51-71.Google Scholar
Dozie-Nwachukwu, S., Obayemi, J. D., Danyuo, Y., Jingjie, H., Cathy, C., Anuku, N., Odusanya, O. S., Malatesta, K. and Soboyejo, W. O.A Comparative Study of the Adhesion of Biosynthesized Gold and Conjugated Gold/Prodigiosin Nanoparticles to Triple Negative Breast Cancer Cells. J. of Mater. Sci.: Mater. in Med. (JMSM), 28 (2017) 143.Google ScholarPubMed
Xiaoming, L., Guangshuai, S., Junsheng, Y., Wei, Y., Zhaodi, R., Xiaohui, W., Xi, X., Hui-Jiuan, C. and Xiaodong, C.Laser heating of metallic nanoparticles for photothermal ablation applications. AIP Advances. 7, (2017) 025308.Google Scholar
Xijian, L., Bo, L., Fanfan, F., Kaibing, X., Rujia, Z., Qian, W., Bingjie, Z., Zhigang, C. and Junqing, H.Facile synthesis of biocompatible cysteine-coated cus nanoparticles with high photothermal conversion efficiency for cancer therapy. The Royal Society of Chemistry Dalton Transactions. 30, (2014).Google Scholar
Hessel, C. M., Pattani, V. P., Rasch, M., Panthani, M. G., Koo, B., Tunnell, J. W. and Korgel, B.Copper Selenide Nanocrystals for Photothermal Therapy. A., Nano Lett. 11 (2011) 2560-2566.CrossRefGoogle ScholarPubMed
Huanga, Xiaohua, Mostafa, A. El-Sayeda. Gold nanoparticles: Optical properties and implementations in cancer diagnosis and photothermal therapy. J Adv Res. 1(1) (2010)13-28.CrossRefGoogle Scholar