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Systems Biology and Systems Pharmacology ofThrombosis

Published online by Cambridge University Press:  31 July 2014

M.A. Panteleev ,
A.N. Sveshnikova ,
A.V. Belyaev ,
D.Y. Nechipurenko ,
I. Gudich ,
S.I. Obydenny ,
N. Dovlatova ,
S.C. Fox  and
E.L. Holmuhamedov
M.A. Panteleev*
Affiliation:
Federal Research and Clinical Center of Pediatric Hematology Oncology and Immunology, 117198 Moscow, Russia Center for Theoretical Problems of Physicochemical Pharmacology Russian Academy of Sciences, 119991 Moscow, Russia Faculty of Physics, Moscow State University, 119899 Moscow, Russia National Research Center for Hematology, 125167 Moscow, Russia
A.N. Sveshnikova
Affiliation:
Federal Research and Clinical Center of Pediatric Hematology Oncology and Immunology, 117198 Moscow, Russia Center for Theoretical Problems of Physicochemical Pharmacology Russian Academy of Sciences, 119991 Moscow, Russia Faculty of Physics, Moscow State University, 119899 Moscow, Russia
A.V. Belyaev
Affiliation:
Federal Research and Clinical Center of Pediatric Hematology Oncology and Immunology, 117198 Moscow, Russia Center for Theoretical Problems of Physicochemical Pharmacology Russian Academy of Sciences, 119991 Moscow, Russia
D.Y. Nechipurenko
Affiliation:
Faculty of Physics, Moscow State University, 119899 Moscow, Russia
I. Gudich
Affiliation:
Federal Research and Clinical Center of Pediatric Hematology Oncology and Immunology, 117198 Moscow, Russia Center for Theoretical Problems of Physicochemical Pharmacology Russian Academy of Sciences, 119991 Moscow, Russia
S.I. Obydenny
Affiliation:
Federal Research and Clinical Center of Pediatric Hematology Oncology and Immunology, 117198 Moscow, Russia Center for Theoretical Problems of Physicochemical Pharmacology Russian Academy of Sciences, 119991 Moscow, Russia
N. Dovlatova
Affiliation:
Cardiovascular Medicine, University of Nottingham, Nottingham, UK
S.C. Fox
Affiliation:
Cardiovascular Medicine, University of Nottingham, Nottingham, UK
E.L. Holmuhamedov
Affiliation:
Center for Integrative Research on Cardiovascular Aging Aurora University of Wisconsin Medical Group, Aurora Health Care Milwaukee, Wisconsin, United States of America Institute of Theoretical and Experimental Biophysics Russian Academy of Sciences, 142290 Pushchino, Russia
*
⋆Corresponding author. E-mail: [email protected]
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Abstract

Thrombus formation in flowing blood is a complex time- and space-dependent process ofcell adhesion and fibrin gel formation controlled by huge intricate networks ofbiochemical reactions. This combination of complex biochemistry, non-Newtonianhydrodynamics, and transport processes makes thrombosis difficult to understand. That iswhy numerous attempts to use mathematical modeling for this purpose were undertaken duringthe last decade. In particular, recent years witnessed something of a transition from the“systems biology” to the “systems pharmacology/systems medicine” stage: computationalmodeling is being increasingly applied to practical problems such as drug development,investigation of particular events underlying disease, analysis of the mechanism(s) ofdrug’s action, determining an optimal dosing protocols, etc. Here we review recentadvances and challenges in our understanding of thrombus formation.

Keywords

systems biologysystems pharmacologythrombosishemostasisplateletsblood coagulation
Type
Research Article
Information
Mathematical Modelling of Natural Phenomena , Volume 9 , Issue 6: Blood flows , 2014 , pp. 4 - 16
Copyright
© EDP Sciences, 2014

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