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Optimal Control of a Cancer Cell Model withDelay

Published online by Cambridge University Press:  28 April 2010

C. Collins ,
K.R. Fister  and
M. Williams
C. Collins
Affiliation:
Department of Mathematics, University of Tennessee, Knoxville, TN 37996 USA
K.R. Fister*
Affiliation:
Department of Mathematics and Statistics, Murray State University, Murray, KY 42071 USA
M. Williams
Affiliation:
Department of Mathematics, University of Nebraska, Lincoln, NE 68588 USA
*
*Corresponding author. E-mail:[email protected]
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Abstract

In this paper, we look at a model depicting the relationship of cancer cells in differentdevelopment stages with immune cells and a cell cycle specific chemotherapy drug. Themodel includes a constant delay in the mitotic phase. By applying optimal control theory,we seek to minimize the cost associated with the chemotherapy drug and to minimize thenumber of tumor cells. Global existence of a solution has been shown for this model andexistence of an optimal control has also been proven. Optimality conditions andcharacterization of the control are discussed.

Keywords

cancer dynamicsoptimal control
Type
Research Article
Information
Mathematical Modelling of Natural Phenomena , Volume 5 , Issue 3: Mathematical modeling in the medical sciences , 2010 , pp. 63 - 75
Copyright
© EDP Sciences, 2010

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