Hostname: page-component-78c5997874-dh8gc Total loading time: 0 Render date: 2024-11-04T19:45:37.965Z Has data issue: false hasContentIssue false

On the Use of the Hill Functions in Mathematical Modelsof Gene Regulatory Networks

Published online by Cambridge University Press:  22 October 2008

M. Santillán*
Affiliation:
Centro de Investigación y de Estudios Avanzados del IPN Unidad Monterrey Vía del Conocimiento 201 Parque de Investigación e Innovación Tecnológica Autopista Monterrey-Aeropuerto km 9.5, 66600 Apodaca NL, México
Get access

Abstract

Hill functions follow from the equilibrium state of the reaction in which n ligands simultaneouslybind a single receptor. This result if often employed to interpret the Hill coefficient asthe number of ligand binding sites in all kinds of reaction schemes. Here, we study the equilibriumstates of the reactions in which n ligand bind a receptor sequentially, both non-cooperatively andin a cooperative fashion. The main outcomes of such analysis are that: n is not a good estimate,but only an upper bound, for the Hill coefficient; while the Hill coefficient depends quite stronglyon the cooperativity level among ligands. We finally use these results to discuss the feasibilityand constrains of using Hill functions to model the regulatory functions in mathematical models ofgene regulatory networks.

Type
Research Article
Copyright
© EDP Sciences, 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)